4-(Isoxazol-3-yl)pyrimidines from Pyrimidinyl Nitrile Oxides
Publication type: Journal Article
Publication date: 2008-11-12
scimago Q3
wos Q3
SJR: 0.437
CiteScore: 3.3
Impact factor: 1.4
ISSN: 09365214, 14372096
Organic Chemistry
Abstract
The 1,3-dipolar cycloaddition reaction of pyrimidinyl aldoxime derived nitrile oxides and alkynes delivers 4-(isoxazol-3-yl)pyrimidines. The procedures reported accommodate three points of diversification around this bisheterocyclic scaffold and the resulting library of compounds has been added to the National Institutes of Health repository (ca. 10 mg of each with >90% purity) for pilot-scale biomedical studies with bioassay data available at the National Center for Biotechnology Information PubChem database.
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Kurth M. et al. 4-(Isoxazol-3-yl)pyrimidines from Pyrimidinyl Nitrile Oxides // Synlett. 2008. Vol. 2008. No. 19. pp. 3036-3040.
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Kurth M., Choung W., Sparks T., Sparks T. 4-(Isoxazol-3-yl)pyrimidines from Pyrimidinyl Nitrile Oxides // Synlett. 2008. Vol. 2008. No. 19. pp. 3036-3040.
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TY - JOUR
DO - 10.1055/s-0028-1087346
UR - https://doi.org/10.1055/s-0028-1087346
TI - 4-(Isoxazol-3-yl)pyrimidines from Pyrimidinyl Nitrile Oxides
T2 - Synlett
AU - Kurth, Mark
AU - Choung, Wonken
AU - Sparks, Thomas
AU - Sparks, Thomas
PY - 2008
DA - 2008/11/12
PB - Georg Thieme Verlag KG
SP - 3036-3040
IS - 19
VL - 2008
SN - 0936-5214
SN - 1437-2096
ER -
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BibTex (up to 50 authors)
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@article{2008_Kurth,
author = {Mark Kurth and Wonken Choung and Thomas Sparks and Thomas Sparks},
title = {4-(Isoxazol-3-yl)pyrimidines from Pyrimidinyl Nitrile Oxides},
journal = {Synlett},
year = {2008},
volume = {2008},
publisher = {Georg Thieme Verlag KG},
month = {nov},
url = {https://doi.org/10.1055/s-0028-1087346},
number = {19},
pages = {3036--3040},
doi = {10.1055/s-0028-1087346}
}
Cite this
MLA
Copy
Kurth, Mark, et al. “4-(Isoxazol-3-yl)pyrimidines from Pyrimidinyl Nitrile Oxides.” Synlett, vol. 2008, no. 19, Nov. 2008, pp. 3036-3040. https://doi.org/10.1055/s-0028-1087346.
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