Simple and Efficient Procedure for a Multigram Synthesis of Both trans- and cis-1-Amino-2-(trifluoromethyl)cyclopropane-1-carboxylic Acid
Publication type: Journal Article
Publication date: 2009-11-20
scimago Q2
wos Q2
SJR: 0.559
CiteScore: 4.6
Impact factor: 2.3
ISSN: 00397881, 1437210X
Catalysis
Organic Chemistry
Abstract
A simple and efficient procedure for the multigram synthesis of both (±)-trans- and (+)-cis-1-amino-2-(trifluoromethyl)cyclopropane-1-carboxylic acid was developed. The key step of the synthesis is the addition of 1-diazo-2,2,2-trifluoroethane to methyl 2-[(tert-butoxycarbonyl)amino]acrylate, followed by thermal decomposition of the resulting pyrazoline. Gram quantities of transand cis-1-amino-2-(trifluoromethyl)cyclopropane-1-carboxylic acid were easily prepared from L -serine in one synthetic run.
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Total citations:
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Citations from 2024:
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GOST
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Mykhailiuk P. et al. Simple and Efficient Procedure for a Multigram Synthesis of Both trans- and cis-1-Amino-2-(trifluoromethyl)cyclopropane-1-carboxylic Acid // Synthesis. 2009. Vol. 2010. No. 03. pp. 443-446.
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Mykhailiuk P., Mykhailiuk P. K., Voievoda N., Volochnyuk D., Komarov I. Simple and Efficient Procedure for a Multigram Synthesis of Both trans- and cis-1-Amino-2-(trifluoromethyl)cyclopropane-1-carboxylic Acid // Synthesis. 2009. Vol. 2010. No. 03. pp. 443-446.
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RIS
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TY - JOUR
DO - 10.1055/s-0029-1217141
UR - https://doi.org/10.1055/s-0029-1217141
TI - Simple and Efficient Procedure for a Multigram Synthesis of Both trans- and cis-1-Amino-2-(trifluoromethyl)cyclopropane-1-carboxylic Acid
T2 - Synthesis
AU - Mykhailiuk, Pavel
AU - Mykhailiuk, Pavel K.
AU - Voievoda, Nataliia
AU - Volochnyuk, Dmitry
AU - Komarov, Igor
PY - 2009
DA - 2009/11/20
PB - Georg Thieme Verlag KG
SP - 443-446
IS - 03
VL - 2010
SN - 0039-7881
SN - 1437-210X
ER -
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BibTex (up to 50 authors)
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@article{2009_Mykhailiuk,
author = {Pavel Mykhailiuk and Pavel K. Mykhailiuk and Nataliia Voievoda and Dmitry Volochnyuk and Igor Komarov},
title = {Simple and Efficient Procedure for a Multigram Synthesis of Both trans- and cis-1-Amino-2-(trifluoromethyl)cyclopropane-1-carboxylic Acid},
journal = {Synthesis},
year = {2009},
volume = {2010},
publisher = {Georg Thieme Verlag KG},
month = {nov},
url = {https://doi.org/10.1055/s-0029-1217141},
number = {03},
pages = {443--446},
doi = {10.1055/s-0029-1217141}
}
Cite this
MLA
Copy
Mykhailiuk, Pavel, et al. “Simple and Efficient Procedure for a Multigram Synthesis of Both trans- and cis-1-Amino-2-(trifluoromethyl)cyclopropane-1-carboxylic Acid.” Synthesis, vol. 2010, no. 03, Nov. 2009, pp. 443-446. https://doi.org/10.1055/s-0029-1217141.