Preparation of 2-Azabicyclo[2.1.1]hexane Hydrochloride
Michael Siu
1
,
Ai-Min Li
1
,
Haili Liao
2
,
梁琨 Kun Liang
2
,
Yang Shen
2
,
Qing-feng Liang
2
,
Yang Shen
2
,
Daniel Shore
2
,
Elisia Villemure
1
,
Michael Siu
1
,
Malcolm P Huestis
1
1
Discovery Chemistry, Genentech, Inc.
2
Pharmaron Beijing Co. Ltd.
|
Publication type: Journal Article
Publication date: 2016-07-07
scimago Q3
wos Q3
SJR: 0.437
CiteScore: 3.3
Impact factor: 1.4
ISSN: 09365214, 14372096
Organic Chemistry
Abstract
A batchwise, multigram preparation of 2-azabicyclo-[2.1.1]hexane hydrochloride (1·HCl) was developed, delivering a total of 195 grams of material. The key synthetic step involves an intramolecular displacement of a primary alkyl chloride with a tert-butylsulfinamide to forge the [2.1.1]-bicyclic ring system.
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Metrics
15
Total citations:
15
Citations from 2024:
11
(73.33%)
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MLA
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GOST
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Siu M. et al. Preparation of 2-Azabicyclo[2.1.1]hexane Hydrochloride // Synlett. 2016. Vol. 27. No. 15. pp. 2251-2253.
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Siu M., Li A., Liao H., Kun Liang 梁., Shen Y., Liang Q., Shen Y., Shore D., Villemure E., Siu M., Huestis M. P. Preparation of 2-Azabicyclo[2.1.1]hexane Hydrochloride // Synlett. 2016. Vol. 27. No. 15. pp. 2251-2253.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1055/s-0035-1562380
UR - https://doi.org/10.1055/s-0035-1562380
TI - Preparation of 2-Azabicyclo[2.1.1]hexane Hydrochloride
T2 - Synlett
AU - Siu, Michael
AU - Li, Ai-Min
AU - Liao, Haili
AU - Kun Liang, 梁琨
AU - Shen, Yang
AU - Liang, Qing-feng
AU - Shen, Yang
AU - Shore, Daniel
AU - Villemure, Elisia
AU - Siu, Michael
AU - Huestis, Malcolm P
PY - 2016
DA - 2016/07/07
PB - Georg Thieme Verlag KG
SP - 2251-2253
IS - 15
VL - 27
SN - 0936-5214
SN - 1437-2096
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2016_Siu,
author = {Michael Siu and Ai-Min Li and Haili Liao and 梁琨 Kun Liang and Yang Shen and Qing-feng Liang and Yang Shen and Daniel Shore and Elisia Villemure and Michael Siu and Malcolm P Huestis},
title = {Preparation of 2-Azabicyclo[2.1.1]hexane Hydrochloride},
journal = {Synlett},
year = {2016},
volume = {27},
publisher = {Georg Thieme Verlag KG},
month = {jul},
url = {https://doi.org/10.1055/s-0035-1562380},
number = {15},
pages = {2251--2253},
doi = {10.1055/s-0035-1562380}
}
Cite this
MLA
Copy
Siu, Michael, et al. “Preparation of 2-Azabicyclo[2.1.1]hexane Hydrochloride.” Synlett, vol. 27, no. 15, Jul. 2016, pp. 2251-2253. https://doi.org/10.1055/s-0035-1562380.
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