Isoxazol-5-ones as Strategic Building Blocks in Organic Synthesis
Publication type: Journal Article
Publication date: 2018-05-17
scimago Q2
wos Q2
SJR: 0.559
CiteScore: 4.6
Impact factor: 2.3
ISSN: 00397881, 1437210X
Catalysis
Organic Chemistry
Abstract
Isoxazol-5-one rings have been identified as relevant motifs in drug candidates, agrochemicals, and materials. Furthermore, this heterocycle has been also applied as a versatile building block for the preparation of a variety of densely functionalized molecules. This short review will present the most representative applications of isoxazol-5-ones in organic synthesis while discussing their properties and reactivity.
1 Introduction
1.1 General Aspects
1.1.1 Tautomerism
1.1.2 Importance: Natural Products Isolation, Biological Activity, and Materials
1.1.3 Preparation Methods
2 Isoxazol-5-ones in Organic Synthesis
2.1 General Reactivity
2.2 Specific Examples
2.2.1 Alkylation Strategies
2.2.2 Alkyne Synthesis
2.2.3 Annulation Reactions
2.2.4 N–O Bond Insertions
2.2.4.1 Preparation of 1,3-Oxazin-6-ones
3 Conclusions
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Total citations:
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Citations from 2024:
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(14%)
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GOST
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Da Silva A. et al. Isoxazol-5-ones as Strategic Building Blocks in Organic Synthesis // Synthesis. 2018. Vol. 50. No. 13. pp. 2473-2489.
GOST all authors (up to 50)
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Da Silva A., Fernandes A., Thurow S., Stivanin M., Jurberg I. D. Isoxazol-5-ones as Strategic Building Blocks in Organic Synthesis // Synthesis. 2018. Vol. 50. No. 13. pp. 2473-2489.
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RIS
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TY - JOUR
DO - 10.1055/s-0036-1589534
UR - https://doi.org/10.1055/s-0036-1589534
TI - Isoxazol-5-ones as Strategic Building Blocks in Organic Synthesis
T2 - Synthesis
AU - Da Silva, Amanda
AU - Fernandes, Alessandra
AU - Thurow, Samuel
AU - Stivanin, Mateus
AU - Jurberg, Igor D
PY - 2018
DA - 2018/05/17
PB - Georg Thieme Verlag KG
SP - 2473-2489
IS - 13
VL - 50
SN - 0039-7881
SN - 1437-210X
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2018_Da Silva,
author = {Amanda Da Silva and Alessandra Fernandes and Samuel Thurow and Mateus Stivanin and Igor D Jurberg},
title = {Isoxazol-5-ones as Strategic Building Blocks in Organic Synthesis},
journal = {Synthesis},
year = {2018},
volume = {50},
publisher = {Georg Thieme Verlag KG},
month = {may},
url = {https://doi.org/10.1055/s-0036-1589534},
number = {13},
pages = {2473--2489},
doi = {10.1055/s-0036-1589534}
}
Cite this
MLA
Copy
Da Silva, Amanda, et al. “Isoxazol-5-ones as Strategic Building Blocks in Organic Synthesis.” Synthesis, vol. 50, no. 13, May. 2018, pp. 2473-2489. https://doi.org/10.1055/s-0036-1589534.