RoFo Fortschritte auf dem Gebiet der Rontgenstrahlen und der Bildgebenden Verfahren, volume 177, issue 06, pages 864-871
Quantifizierung mikroangiopathischer Hirnparenchymläsionen zur Abgrenzung altersnormaler gegenüber pathologischer Ausprägung bei Altersdemenzen
Publication type: Journal Article
Publication date: 2005-06-01
Quartile SCImago
Q4
Quartile WOS
Q4
Impact factor: 1.8
ISSN: 14389029, 14389010
Radiology, Nuclear Medicine and imaging
Abstract
To quantify microangiopathic lesions in the cerebral white matter and to develop age-corrected cut-off values for separating normal from dementia-related pathological lesions.In a memory clinic, 338 patients were investigated neuropsychiatrically by a psychological test battery and by MRI. Using a FLAIR sequence and a newly developed rating scale, white matter lesions (WMLs) were quantified with respect to localization, number and intensity, and these ratings were condensed into a score. The WML scores were correlated with the mini-mental state examination (MMSE) and clinical dementia rating (CDR) score in dementia patients. A non-linear smoothing procedure was used to calculate age-related mean values and confidence intervals, separate for cognitively intact subjects and dementia patients.The WML scores correlated highly significantly with age in cognitively intact subjects and with psychometric scores in dementia patients. Age-adjusted WML scores of cognitively intact subjects were significantly different from those of dementia patients with respect to the whole brain as well as to the frontal lobe. Mean value and confidence intervals adjusted for age significantly separated dementia patients from cognitively intact subjects over an age range of 54 through 84 years.A rating scale for the quantification of WML was validated and age-adjusted mean values with their confidence intervals for a diagnostically relevant age range were developed. This allows an easy to handle, fast and reliable diagnosis of the vascular component in senile dementia.
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Citations by publishers
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Wiley
2 publications, 40%
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Springer Nature
1 publication, 20%
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American Society of Neuoradiology
1 publication, 20%
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Hentschel F. Quantifizierung mikroangiopathischer Hirnparenchymläsionen zur Abgrenzung altersnormaler gegenüber pathologischer Ausprägung bei Altersdemenzen // RoFo Fortschritte auf dem Gebiet der Rontgenstrahlen und der Bildgebenden Verfahren. 2005. Vol. 177. No. 06. pp. 864-871.
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Hentschel F. Quantifizierung mikroangiopathischer Hirnparenchymläsionen zur Abgrenzung altersnormaler gegenüber pathologischer Ausprägung bei Altersdemenzen // RoFo Fortschritte auf dem Gebiet der Rontgenstrahlen und der Bildgebenden Verfahren. 2005. Vol. 177. No. 06. pp. 864-871.
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TY - JOUR
DO - 10.1055/s-2005-858193
UR - https://doi.org/10.1055/s-2005-858193
TI - Quantifizierung mikroangiopathischer Hirnparenchymläsionen zur Abgrenzung altersnormaler gegenüber pathologischer Ausprägung bei Altersdemenzen
T2 - RoFo Fortschritte auf dem Gebiet der Rontgenstrahlen und der Bildgebenden Verfahren
AU - Hentschel, F.
PY - 2005
DA - 2005/06/01
PB - Thieme
SP - 864-871
IS - 06
VL - 177
SN - 1438-9029
SN - 1438-9010
ER -
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@article{2005_Hentschel,
author = {F. Hentschel},
title = {Quantifizierung mikroangiopathischer Hirnparenchymläsionen zur Abgrenzung altersnormaler gegenüber pathologischer Ausprägung bei Altersdemenzen},
journal = {RoFo Fortschritte auf dem Gebiet der Rontgenstrahlen und der Bildgebenden Verfahren},
year = {2005},
volume = {177},
publisher = {Thieme},
month = {jun},
url = {https://doi.org/10.1055/s-2005-858193},
number = {06},
pages = {864--871},
doi = {10.1055/s-2005-858193}
}
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Hentschel, F.. “Quantifizierung mikroangiopathischer Hirnparenchymläsionen zur Abgrenzung altersnormaler gegenüber pathologischer Ausprägung bei Altersdemenzen.” RoFo Fortschritte auf dem Gebiet der Rontgenstrahlen und der Bildgebenden Verfahren, vol. 177, no. 06, Jun. 2005, pp. 864-871. https://doi.org/10.1055/s-2005-858193.