Synlett, volume 2005, issue 19, pages 2919-2922
Lipase-Catalyzed Asymmetric Dealkoxylcarbonylation of σ-Symmetrical β-Ketodiesters and Its Application to the Synthesis of (-)-Podocarpic Acid
Manabu Node
,
Takahiro Katoh
,
Ken Ichiro Awasaguchi
,
Daisuke Mori
,
Hiroyuki Kimura
,
Tetsuya Kajimoto
Publication type: Journal Article
Publication date: 2005-10-27
Journal:
Synlett
scimago Q3
wos Q3
SJR: 0.450
CiteScore: 3.4
Impact factor: 1.7
ISSN: 09365214, 14372096
Organic Chemistry
Abstract
Optically active 2,6-dimethylcyclohexanone-2-carboxylate was prepared by PLE-catalyzed dealkoxycarbonylation of σ-symmetrical β-ketodiesters, which possess quartemary carbons at α- and α'-positions. Moreover, (-)-podocarpic acid was prepared in a short sequence from 2,6-dimethylcyclohexanone-2-carboxylate.
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