Synthesis, volume 2006, issue 14, pages 2440-2443
Simple and Efficient Multigram Scale Synthesis of 1-Aminocyclopent-3-ene-1-carboxylic Acid
Carlos Cativiela
Publication type: Journal Article
Publication date: 2006-07-07
Catalysis
Organic Chemistry
Abstract
A very simple and inexpensive synthesis of the valuable intermediate 1-aminocyclopent-3-ene-1-carboxylic acid on a multigram scale and with a high overall yield (80%) is reported. The efficiency of the procedure relies on the ready accessibility and high reactivity of the glycine equivalent used as the starting material.
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