Regioselective γ-Alkylation of tert-Butyl 2,4-Dioxopiperidine-1-carboxylate
Publication type: Journal Article
Publication date: 2007-10-09
scimago Q2
wos Q2
SJR: 0.559
CiteScore: 4.6
Impact factor: 2.3
ISSN: 00397881, 1437210X
Catalysis
Organic Chemistry
Abstract
A method for the regioselective γ-alkylation of N-Boc protected piperidine-2,4-dione is reported. The use of a wide variety of electrophiles demonstrates the robustness of the procedure. The reaction offers facile access to synthetically useful derivatives. A mechanistic hypothesis is given, explaining the essential role played by the lithium counter-ion.
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Orsini P., Maccario A., COLOMBO N. Regioselective γ-Alkylation of tert-Butyl 2,4-Dioxopiperidine-1-carboxylate // Synthesis. 2007. Vol. 2007. No. 20. pp. 3185-3190.
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Orsini P., Maccario A., COLOMBO N. Regioselective γ-Alkylation of tert-Butyl 2,4-Dioxopiperidine-1-carboxylate // Synthesis. 2007. Vol. 2007. No. 20. pp. 3185-3190.
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RIS
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TY - JOUR
DO - 10.1055/s-2007-990792
UR - https://doi.org/10.1055/s-2007-990792
TI - Regioselective γ-Alkylation of tert-Butyl 2,4-Dioxopiperidine-1-carboxylate
T2 - Synthesis
AU - Orsini, Paolo
AU - Maccario, Alessandro
AU - COLOMBO, N.
PY - 2007
DA - 2007/10/09
PB - Georg Thieme Verlag KG
SP - 3185-3190
IS - 20
VL - 2007
SN - 0039-7881
SN - 1437-210X
ER -
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BibTex (up to 50 authors)
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@article{2007_Orsini,
author = {Paolo Orsini and Alessandro Maccario and N. COLOMBO},
title = {Regioselective γ-Alkylation of tert-Butyl 2,4-Dioxopiperidine-1-carboxylate},
journal = {Synthesis},
year = {2007},
volume = {2007},
publisher = {Georg Thieme Verlag KG},
month = {oct},
url = {https://doi.org/10.1055/s-2007-990792},
number = {20},
pages = {3185--3190},
doi = {10.1055/s-2007-990792}
}
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MLA
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Orsini, Paolo, et al. “Regioselective γ-Alkylation of tert-Butyl 2,4-Dioxopiperidine-1-carboxylate.” Synthesis, vol. 2007, no. 20, Oct. 2007, pp. 3185-3190. https://doi.org/10.1055/s-2007-990792.