Ortho-Formylation of Phenols: the Casnati-Skattebøl Reaction in the Synthesis of Biologically Active Substances.
Publication type: Journal Article
Publication date: 2025-01-20
scimago Q2
wos Q2
SJR: 0.559
CiteScore: 4.6
Impact factor: 2.3
ISSN: 00397881, 1437210X
Abstract
The Casnati–Skattebøl reaction is an effective method for achieving ortho-formylation of phenols to provide salicylaldehydes. The conversion involves the reaction of magnesium phenolates with formaldehyde followed by an oxidation of the intermediate hydroxymethyl group. This reaction has been used in the synthesis of numerous biologically active substances and natural products, which is the subject of this review.
1 Introduction
2 General Aspects
2.1 Synthesis of Compounds with Biological Activity
2.2 Alternative Formylation Methods
3 Summary
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Klumpp D. A. et al. Ortho-Formylation of Phenols: the Casnati-Skattebøl Reaction in the Synthesis of Biologically Active Substances. // Synthesis. 2025.
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Klumpp D. A., Debt T., Littich R. Ortho-Formylation of Phenols: the Casnati-Skattebøl Reaction in the Synthesis of Biologically Active Substances. // Synthesis. 2025.
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TY - JOUR
DO - 10.1055/a-2520-0095
UR - http://www.thieme-connect.de/DOI/DOI?10.1055/a-2520-0095
TI - Ortho-Formylation of Phenols: the Casnati-Skattebøl Reaction in the Synthesis of Biologically Active Substances.
T2 - Synthesis
AU - Klumpp, Douglas A.
AU - Debt, Titas
AU - Littich, Ryan
PY - 2025
DA - 2025/01/20
PB - Georg Thieme Verlag KG
SN - 0039-7881
SN - 1437-210X
ER -
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@article{2025_Klumpp,
author = {Douglas A. Klumpp and Titas Debt and Ryan Littich},
title = {Ortho-Formylation of Phenols: the Casnati-Skattebøl Reaction in the Synthesis of Biologically Active Substances.},
journal = {Synthesis},
year = {2025},
publisher = {Georg Thieme Verlag KG},
month = {jan},
url = {http://www.thieme-connect.de/DOI/DOI?10.1055/a-2520-0095},
doi = {10.1055/a-2520-0095}
}
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