том 55 издание 12 страницы 738-743

Synthesis and Pharmacological Evaluation of Novel Quinoxalines as Potential Nonulcerogenic Anti-inflammatory and Analgesic Agents

Тип публикацииJournal Article
Дата публикации2011-12-23
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ISSN00044172, 16167066
Drug Discovery
Краткое описание
Some new substituted quinoxaline and furo[2,3-b]quinoxaline derivatives have been synthesized and tested for their anti-inflammatory and analgesic activities and for their ulcerogenic potential. The pharmacological evaluation of selected synthesized compounds revealed that 5a was equipotent and compounds 3, 4b, 4e and 5b possessed strong anti-inflammatory activity in chronic inflammatory models compared with indometacin (CAS 53-86-1) as reference drug. In addition, compound 4a was the safest one and the others showed little ulcerogenic activity. All the tested compounds showed moderate analgesic activity compared to the reference drug.
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ГОСТ |
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Ismail M. M. et al. Synthesis and Pharmacological Evaluation of Novel Quinoxalines as Potential Nonulcerogenic Anti-inflammatory and Analgesic Agents // Arzneimittelforschung. 2011. Vol. 55. No. 12. pp. 738-743.
ГОСТ со всеми авторами (до 50) Скопировать
Ismail M. M., Ammar Y., Khan I. A., El Zahaby H., Mahmoud S. A. Synthesis and Pharmacological Evaluation of Novel Quinoxalines as Potential Nonulcerogenic Anti-inflammatory and Analgesic Agents // Arzneimittelforschung. 2011. Vol. 55. No. 12. pp. 738-743.
RIS |
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TY - JOUR
DO - 10.1055/s-0031-1296923
UR - https://doi.org/10.1055/s-0031-1296923
TI - Synthesis and Pharmacological Evaluation of Novel Quinoxalines as Potential Nonulcerogenic Anti-inflammatory and Analgesic Agents
T2 - Arzneimittelforschung
AU - Ismail, Magda M.F
AU - Ammar, Yousry
AU - Khan, Ikhlas A.
AU - El Zahaby, Heba
AU - Mahmoud, Sawsan A
PY - 2011
DA - 2011/12/23
PB - Georg Thieme Verlag KG
SP - 738-743
IS - 12
VL - 55
PMID - 16430027
SN - 0004-4172
SN - 1616-7066
ER -
BibTex |
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@article{2011_Ismail,
author = {Magda M.F Ismail and Yousry Ammar and Ikhlas A. Khan and Heba El Zahaby and Sawsan A Mahmoud},
title = {Synthesis and Pharmacological Evaluation of Novel Quinoxalines as Potential Nonulcerogenic Anti-inflammatory and Analgesic Agents},
journal = {Arzneimittelforschung},
year = {2011},
volume = {55},
publisher = {Georg Thieme Verlag KG},
month = {dec},
url = {https://doi.org/10.1055/s-0031-1296923},
number = {12},
pages = {738--743},
doi = {10.1055/s-0031-1296923}
}
MLA
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Ismail, Magda M.F, et al. “Synthesis and Pharmacological Evaluation of Novel Quinoxalines as Potential Nonulcerogenic Anti-inflammatory and Analgesic Agents.” Arzneimittelforschung, vol. 55, no. 12, Dec. 2011, pp. 738-743. https://doi.org/10.1055/s-0031-1296923.
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