Reductive Amination by Continuous-Flow Hydrogenation: Direct and Scalable Synthesis of a Benzylpiperazine
1
Janssen Research & Development, L.L.C.
Publication type: Journal Article
Publication date: 2012-07-02
scimago Q2
wos Q2
SJR: 0.559
CiteScore: 4.6
Impact factor: 2.3
ISSN: 00397881, 1437210X
Catalysis
Organic Chemistry
Abstract
A benzylpiperazine was prepared directly from the corresponding benzaldehyde and piperazine on a continuous-flow hydrogenation apparatus. The synthesis was protecting group free, safe, and environmentally friendly. Large-scale synthesis under flow hydrogenation conditions was also demonstrated.
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Metrics
26
Total citations:
26
Citations from 2024:
3
(11.54%)
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MLA
Cite this
GOST
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Liu J., Fitzgerald A., Mani N. S. Reductive Amination by Continuous-Flow Hydrogenation: Direct and Scalable Synthesis of a Benzylpiperazine // Synthesis. 2012. Vol. 44. No. 15. pp. 2469-2473.
GOST all authors (up to 50)
Copy
Liu J., Fitzgerald A., Mani N. S. Reductive Amination by Continuous-Flow Hydrogenation: Direct and Scalable Synthesis of a Benzylpiperazine // Synthesis. 2012. Vol. 44. No. 15. pp. 2469-2473.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1055/s-0032-1316550
UR - https://doi.org/10.1055/s-0032-1316550
TI - Reductive Amination by Continuous-Flow Hydrogenation: Direct and Scalable Synthesis of a Benzylpiperazine
T2 - Synthesis
AU - Liu, Jing
AU - Fitzgerald, Anne
AU - Mani, Neelakandha S.
PY - 2012
DA - 2012/07/02
PB - Georg Thieme Verlag KG
SP - 2469-2473
IS - 15
VL - 44
SN - 0039-7881
SN - 1437-210X
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2012_Liu,
author = {Jing Liu and Anne Fitzgerald and Neelakandha S. Mani},
title = {Reductive Amination by Continuous-Flow Hydrogenation: Direct and Scalable Synthesis of a Benzylpiperazine},
journal = {Synthesis},
year = {2012},
volume = {44},
publisher = {Georg Thieme Verlag KG},
month = {jul},
url = {https://doi.org/10.1055/s-0032-1316550},
number = {15},
pages = {2469--2473},
doi = {10.1055/s-0032-1316550}
}
Cite this
MLA
Copy
Liu, Jing, et al. “Reductive Amination by Continuous-Flow Hydrogenation: Direct and Scalable Synthesis of a Benzylpiperazine.” Synthesis, vol. 44, no. 15, Jul. 2012, pp. 2469-2473. https://doi.org/10.1055/s-0032-1316550.