Georg Thieme Verlag KG
Synlett
,  volume 29 ,  issue 07 ,  pages 898-903

Alcohol-Initiated Dinitrile Cyclization in Basic Media: A Route Toward Pyrazino[1,2-a]indole-3-Amines

Publication type: Journal Article
Publication date: 2018-02-12
Georg Thieme Verlag KG
scimago Q3
wos Q3
SJR: 0.437
CiteScore: 3.3
Impact factor: 1.4
ISSN: 09365214, 14372096
Organic Chemistry
Abstract

A selective route to the formation of 1-alkoxypyrazino[1,2-a]indole-3-amines through alcohol-initiated dinitrile cyclization, starting from N-(cyanomethyl)indole-2-carbonitriles under basic conditions, was discovered. The resulting compounds were shown to be unstable in solution, and a three-component reaction of the dinitrile, alcohol, and aromatic aldehyde was used to overcome the problem.

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GOST Copy
Voskressensky L. G. et al. Alcohol-Initiated Dinitrile Cyclization in Basic Media: A Route Toward Pyrazino[1,2-a]indole-3-Amines // Synlett. 2018. Vol. 29. No. 07. pp. 898-903.
GOST all authors (up to 50) Copy
Voskressensky L. G., Festa A., Golantsov N., Storozhenko O., Shumsky A., Varlamov A. Alcohol-Initiated Dinitrile Cyclization in Basic Media: A Route Toward Pyrazino[1,2-a]indole-3-Amines // Synlett. 2018. Vol. 29. No. 07. pp. 898-903.
RIS |
Cite this
RIS Copy
TY - JOUR
DO - 10.1055/s-0036-1591529
UR - https://doi.org/10.1055/s-0036-1591529
TI - Alcohol-Initiated Dinitrile Cyclization in Basic Media: A Route Toward Pyrazino[1,2-a]indole-3-Amines
T2 - Synlett
AU - Voskressensky, Leonid G.
AU - Festa, Alexey
AU - Golantsov, Nikita
AU - Storozhenko, Olga
AU - Shumsky, Alexey
AU - Varlamov, Alexey
PY - 2018
DA - 2018/02/12
PB - Georg Thieme Verlag KG
SP - 898-903
IS - 07
VL - 29
SN - 0936-5214
SN - 1437-2096
ER -
BibTex |
Cite this
BibTex (up to 50 authors) Copy
@article{2018_Voskressensky,
author = {Leonid G. Voskressensky and Alexey Festa and Nikita Golantsov and Olga Storozhenko and Alexey Shumsky and Alexey Varlamov},
title = {Alcohol-Initiated Dinitrile Cyclization in Basic Media: A Route Toward Pyrazino[1,2-a]indole-3-Amines},
journal = {Synlett},
year = {2018},
volume = {29},
publisher = {Georg Thieme Verlag KG},
month = {feb},
url = {https://doi.org/10.1055/s-0036-1591529},
number = {07},
pages = {898--903},
doi = {10.1055/s-0036-1591529}
}
MLA
Cite this
MLA Copy
Voskressensky, Leonid G., et al. “Alcohol-Initiated Dinitrile Cyclization in Basic Media: A Route Toward Pyrazino[1,2-a]indole-3-Amines.” Synlett, vol. 29, no. 07, Feb. 2018, pp. 898-903. https://doi.org/10.1055/s-0036-1591529.