volume 29 issue 04 pages 477-482

2-Phenyl-2,3-dihydrobenzo[d]thiazole: A Mild, Efficient, and Highly Active in situ Generated Chemoselective Reducing Agent for the One-Pot Synthesis of 5-Monoalkylbarbiturates in Water

Publication typeJournal Article
Publication date2017-11-28
scimago Q3
wos Q3
SJR0.437
CiteScore3.3
Impact factor1.4
ISSN09365214, 14372096
Organic Chemistry
Abstract

A metal- and catalyst-free reductive alkylation protocol for the one-pot synthesis of 5-monoalkylbarbiturates from barbituric acids and aldehydes using the in situ generated chemoselective reducing agent 2-phenyl-2,3-dihydrobenzo[d]thiazole from 2-aminothiophenol and benzaldehyde is described. The notable advantages of the protocol are operational simplicity, mild reaction conditions, high yield, short reaction time, and simple workup and purification process which make it highly attractive.

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Deka D., Chandra Deka D. 2-Phenyl-2,3-dihydrobenzo[d]thiazole: A Mild, Efficient, and Highly Active in situ Generated Chemoselective Reducing Agent for the One-Pot Synthesis of 5-Monoalkylbarbiturates in Water // Synlett. 2017. Vol. 29. No. 04. pp. 477-482.
GOST all authors (up to 50) Copy
Deka D., Chandra Deka D. 2-Phenyl-2,3-dihydrobenzo[d]thiazole: A Mild, Efficient, and Highly Active in situ Generated Chemoselective Reducing Agent for the One-Pot Synthesis of 5-Monoalkylbarbiturates in Water // Synlett. 2017. Vol. 29. No. 04. pp. 477-482.
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RIS Copy
TY - JOUR
DO - 10.1055/s-0036-1591725
UR - https://doi.org/10.1055/s-0036-1591725
TI - 2-Phenyl-2,3-dihydrobenzo[d]thiazole: A Mild, Efficient, and Highly Active in situ Generated Chemoselective Reducing Agent for the One-Pot Synthesis of 5-Monoalkylbarbiturates in Water
T2 - Synlett
AU - Deka, Dibakar
AU - Chandra Deka, Dibakar
PY - 2017
DA - 2017/11/28
PB - Georg Thieme Verlag KG
SP - 477-482
IS - 04
VL - 29
SN - 0936-5214
SN - 1437-2096
ER -
BibTex |
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BibTex (up to 50 authors) Copy
@article{2017_Deka,
author = {Dibakar Deka and Dibakar Chandra Deka},
title = {2-Phenyl-2,3-dihydrobenzo[d]thiazole: A Mild, Efficient, and Highly Active in situ Generated Chemoselective Reducing Agent for the One-Pot Synthesis of 5-Monoalkylbarbiturates in Water},
journal = {Synlett},
year = {2017},
volume = {29},
publisher = {Georg Thieme Verlag KG},
month = {nov},
url = {https://doi.org/10.1055/s-0036-1591725},
number = {04},
pages = {477--482},
doi = {10.1055/s-0036-1591725}
}
MLA
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Deka, Dibakar, and Dibakar Chandra Deka. “2-Phenyl-2,3-dihydrobenzo[d]thiazole: A Mild, Efficient, and Highly Active in situ Generated Chemoselective Reducing Agent for the One-Pot Synthesis of 5-Monoalkylbarbiturates in Water.” Synlett, vol. 29, no. 04, Nov. 2017, pp. 477-482. https://doi.org/10.1055/s-0036-1591725.