volume 29 issue 03 pages 326-329

Short Synthesis of the Antidiabetic Octaketide Ethyl 2-(2,3,4-Trimethoxy-6-octanoylphenyl)acetate

Wei Sun 1
Yue Yuan 1
Yue Yuan 1
H S Jun 1
DONGYUN SHIN 1
Seung-Yong Seo 1
Publication typeJournal Article
Publication date2017-11-28
scimago Q3
wos Q3
SJR0.437
CiteScore3.3
Impact factor1.4
ISSN09365214, 14372096
Organic Chemistry
Abstract

A facile and practical approach for the synthesis of ethyl 2-(2,3,4-trimethoxy-6-octanoylphenyl)acetate, an antidiabetic octaketide analogue of cytosporone B, is described. Unlike known approaches for the synthesis of cytosporones and their analogues, the key step of the developed route is a Friedel–Crafts alkylation of 1-(3,4,5-trimethoxyphenyl)octan-1-one with ethyl chloro(methylthio)acetate, followed by desulfurization.

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Sun W. et al. Short Synthesis of the Antidiabetic Octaketide Ethyl 2-(2,3,4-Trimethoxy-6-octanoylphenyl)acetate // Synlett. 2017. Vol. 29. No. 03. pp. 326-329.
GOST all authors (up to 50) Copy
Sun W., Yuan Y., Yuan Y., Jun H. S., SHIN D., Seo S. Short Synthesis of the Antidiabetic Octaketide Ethyl 2-(2,3,4-Trimethoxy-6-octanoylphenyl)acetate // Synlett. 2017. Vol. 29. No. 03. pp. 326-329.
RIS |
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RIS Copy
TY - JOUR
DO - 10.1055/s-0036-1592062
UR - https://doi.org/10.1055/s-0036-1592062
TI - Short Synthesis of the Antidiabetic Octaketide Ethyl 2-(2,3,4-Trimethoxy-6-octanoylphenyl)acetate
T2 - Synlett
AU - Sun, Wei
AU - Yuan, Yue
AU - Yuan, Yue
AU - Jun, H S
AU - SHIN, DONGYUN
AU - Seo, Seung-Yong
PY - 2017
DA - 2017/11/28
PB - Georg Thieme Verlag KG
SP - 326-329
IS - 03
VL - 29
SN - 0936-5214
SN - 1437-2096
ER -
BibTex |
Cite this
BibTex (up to 50 authors) Copy
@article{2017_Sun,
author = {Wei Sun and Yue Yuan and Yue Yuan and H S Jun and DONGYUN SHIN and Seung-Yong Seo},
title = {Short Synthesis of the Antidiabetic Octaketide Ethyl 2-(2,3,4-Trimethoxy-6-octanoylphenyl)acetate},
journal = {Synlett},
year = {2017},
volume = {29},
publisher = {Georg Thieme Verlag KG},
month = {nov},
url = {https://doi.org/10.1055/s-0036-1592062},
number = {03},
pages = {326--329},
doi = {10.1055/s-0036-1592062}
}
MLA
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MLA Copy
Sun, Wei, et al. “Short Synthesis of the Antidiabetic Octaketide Ethyl 2-(2,3,4-Trimethoxy-6-octanoylphenyl)acetate.” Synlett, vol. 29, no. 03, Nov. 2017, pp. 326-329. https://doi.org/10.1055/s-0036-1592062.
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