Synthesis and Antiproliferative Properties of Bifunctional Allocolchicine Derivatives
Publication type: Journal Article
Publication date: 2018-05-28
scimago Q2
wos Q2
SJR: 0.559
CiteScore: 4.6
Impact factor: 2.3
ISSN: 00397881, 1437210X
Catalysis
Organic Chemistry
Abstract
Based on the natural antimitotic agent colchifoline as a lead structure, a series of novel bifunctional allocolchicine congeners were synthesized from commercial colchicine. The new derivatives maintain good cytotoxicity against T3M4, MiaPaCa-2, and PANC-1 cell lines. The presence of functional groups simplifies further modifications of the prepared structures and the design of novel colchicine-derived antitumor compounds with desired pharmacological properties.
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Metrics
11
Total citations:
11
Citations from 2024:
3
(27.27%)
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MLA
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GOST
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Fedorov A. et al. Synthesis and Antiproliferative Properties of Bifunctional Allocolchicine Derivatives // Synthesis. 2018. Vol. 50. No. 14. pp. 2753-2760.
GOST all authors (up to 50)
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Fedorov A., Gracheva I., SVIRSHCHEVSKAYA E., Faerman V., Beletskaya I. Synthesis and Antiproliferative Properties of Bifunctional Allocolchicine Derivatives // Synthesis. 2018. Vol. 50. No. 14. pp. 2753-2760.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1055/s-0037-1610146
UR - https://doi.org/10.1055/s-0037-1610146
TI - Synthesis and Antiproliferative Properties of Bifunctional Allocolchicine Derivatives
T2 - Synthesis
AU - Fedorov, Alexey
AU - Gracheva, Iuliia
AU - SVIRSHCHEVSKAYA, ELENA
AU - Faerman, Vladimir
AU - Beletskaya, Irina
PY - 2018
DA - 2018/05/28
PB - Georg Thieme Verlag KG
SP - 2753-2760
IS - 14
VL - 50
SN - 0039-7881
SN - 1437-210X
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2018_Fedorov,
author = {Alexey Fedorov and Iuliia Gracheva and ELENA SVIRSHCHEVSKAYA and Vladimir Faerman and Irina Beletskaya},
title = {Synthesis and Antiproliferative Properties of Bifunctional Allocolchicine Derivatives},
journal = {Synthesis},
year = {2018},
volume = {50},
publisher = {Georg Thieme Verlag KG},
month = {may},
url = {https://doi.org/10.1055/s-0037-1610146},
number = {14},
pages = {2753--2760},
doi = {10.1055/s-0037-1610146}
}
Cite this
MLA
Copy
Fedorov, Alexey, et al. “Synthesis and Antiproliferative Properties of Bifunctional Allocolchicine Derivatives.” Synthesis, vol. 50, no. 14, May. 2018, pp. 2753-2760. https://doi.org/10.1055/s-0037-1610146.
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