Metal- and Solvent-free Synthesis of Functionalized Dihydrooxazolo[3,2-a]indoles by One-Pot Tandem Assembly of 3H-Indoles and Propargylic Alcohols
Publication type: Journal Article
Publication date: 2018-11-28
scimago Q2
wos Q2
SJR: 0.559
CiteScore: 4.6
Impact factor: 2.3
ISSN: 00397881, 1437210X
Catalysis
Organic Chemistry
Abstract
The reaction of 3H-indoles with tertiary propargylic alcohols to give functionalized dihydrooxazolo[3,2-a]indoles in good to excellent yields has been developed. This metal- and solvent-free, one-pot tandem assembly proceeds under mild conditions (22–60 °C) and is regio- and stereoselective: either the Z- or E-isomers (relative to the double bond) are alternatively formed depending on other functionalized substituents on the propargylic alcohols.
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9
Total citations:
9
Citations from 2024:
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(22.22%)
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Oparina L. A., Trofimov B. A. Metal- and Solvent-free Synthesis of Functionalized Dihydrooxazolo[3,2-a]indoles by One-Pot Tandem Assembly of 3H-Indoles and Propargylic Alcohols // Synthesis. 2018. Vol. 51. No. 06. pp. 1445-1454.
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Oparina L. A., Trofimov B. A. Metal- and Solvent-free Synthesis of Functionalized Dihydrooxazolo[3,2-a]indoles by One-Pot Tandem Assembly of 3H-Indoles and Propargylic Alcohols // Synthesis. 2018. Vol. 51. No. 06. pp. 1445-1454.
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TY - JOUR
DO - 10.1055/s-0037-1610319
UR - https://doi.org/10.1055/s-0037-1610319
TI - Metal- and Solvent-free Synthesis of Functionalized Dihydrooxazolo[3,2-a]indoles by One-Pot Tandem Assembly of 3H-Indoles and Propargylic Alcohols
T2 - Synthesis
AU - Oparina, Ludmila A.
AU - Trofimov, B. A.
PY - 2018
DA - 2018/11/28
PB - Georg Thieme Verlag KG
SP - 1445-1454
IS - 06
VL - 51
SN - 0039-7881
SN - 1437-210X
ER -
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BibTex (up to 50 authors)
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@article{2018_Oparina,
author = {Ludmila A. Oparina and B. A. Trofimov},
title = {Metal- and Solvent-free Synthesis of Functionalized Dihydrooxazolo[3,2-a]indoles by One-Pot Tandem Assembly of 3H-Indoles and Propargylic Alcohols},
journal = {Synthesis},
year = {2018},
volume = {51},
publisher = {Georg Thieme Verlag KG},
month = {nov},
url = {https://doi.org/10.1055/s-0037-1610319},
number = {06},
pages = {1445--1454},
doi = {10.1055/s-0037-1610319}
}
Cite this
MLA
Copy
Oparina, Ludmila A., and B. A. Trofimov. “Metal- and Solvent-free Synthesis of Functionalized Dihydrooxazolo[3,2-a]indoles by One-Pot Tandem Assembly of 3H-Indoles and Propargylic Alcohols.” Synthesis, vol. 51, no. 06, Nov. 2018, pp. 1445-1454. https://doi.org/10.1055/s-0037-1610319.
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