Pyridazine Based Scaffolds as Privileged Structures in anti-Cancer Therapy
Publication type: Journal Article
Publication date: 2017-01-10
scimago Q3
wos Q3
SJR: 0.415
CiteScore: 4.0
Impact factor: 2.1
ISSN: 21949379, 21949387
PubMed ID:
28073115
Drug Discovery
General Medicine
Abstract
Pyridazines, their oxo derivatives; pyridazinone as well as fused bi- or tricyclic pyridazine containing scaffolds are key structural features of many biologically active compounds with diverse pharmacological applications, including cancer therapy. Since protein kinases play prominent role in tumor biology, the inhibition of its signaling pathway is considered an effective therapeutic option for the treatment of cancer.Based on the various advantages of pyridazines in drug design including modulation of the physico-chemical properties, improving ADME and toxicity profile as well as easy and diverse synthetic methods of access, makes them an invaluable tool for designing compounds as future drugs for targeted cancer treatment.In this review, we have compiled and discussed the anticancer potential of pyridazine based scaffold, with special focus on those targeting protein kinase inhibition.
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57
Total citations:
57
Citations from 2025:
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(19.3%)
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GOST
Copy
Jaballah M., Serya R., Abouzid K. A. M. Pyridazine Based Scaffolds as Privileged Structures in anti-Cancer Therapy // Drug Research. 2017. Vol. 67. No. 03. pp. 138-148.
GOST all authors (up to 50)
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Jaballah M., Serya R., Abouzid K. A. M. Pyridazine Based Scaffolds as Privileged Structures in anti-Cancer Therapy // Drug Research. 2017. Vol. 67. No. 03. pp. 138-148.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1055/s-0042-119992
UR - https://doi.org/10.1055/s-0042-119992
TI - Pyridazine Based Scaffolds as Privileged Structures in anti-Cancer Therapy
T2 - Drug Research
AU - Jaballah, Maiy
AU - Serya, Rabah
AU - Abouzid, Khaled Abouzid Mohamed
PY - 2017
DA - 2017/01/10
PB - Georg Thieme Verlag KG
SP - 138-148
IS - 03
VL - 67
PMID - 28073115
SN - 2194-9379
SN - 2194-9387
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2017_Jaballah,
author = {Maiy Jaballah and Rabah Serya and Khaled Abouzid Mohamed Abouzid},
title = {Pyridazine Based Scaffolds as Privileged Structures in anti-Cancer Therapy},
journal = {Drug Research},
year = {2017},
volume = {67},
publisher = {Georg Thieme Verlag KG},
month = {jan},
url = {https://doi.org/10.1055/s-0042-119992},
number = {03},
pages = {138--148},
doi = {10.1055/s-0042-119992}
}
Cite this
MLA
Copy
Jaballah, Maiy, et al. “Pyridazine Based Scaffolds as Privileged Structures in anti-Cancer Therapy.” Drug Research, vol. 67, no. 03, Jan. 2017, pp. 138-148. https://doi.org/10.1055/s-0042-119992.