Photo-Activated DNA Binding and Antimicrobial Activities of Furoquinoline and Pyranoquinolone Alkaloids from Rutaceae
Publication type: Journal Article
Publication date: 2004-06-01
scimago Q2
wos Q2
SJR: 0.427
CiteScore: 4.5
Impact factor: 2.0
ISSN: 00320943, 14390221
PubMed ID:
15229804
Organic Chemistry
Drug Discovery
Pharmacology
Pharmaceutical Science
Molecular Medicine
Complementary and alternative medicine
Analytical Chemistry
Abstract
To find novel photo-active compounds of potential use in photochemotherapy from higher plants, photo-activated antimicrobial and DNA binding activities of the furoquinolines, skimmianine, kokusaginine, and haplopine, and a pyranoquinolone, flindersine, from two species of Rutaceae plants were investigated. TLC overlay assays against a methichillin-resistant strain of Staphylococcus aureus and Candida albicans were employed to test antimicrobial properties. All of the tested compounds showed photo-activated antimicrobial activity against S. aureus in the order of kokusaginine > haplopine, flindersine > skimmianine. Weaker activity was found for C. albicans. Photo-activated DNA binding activity of these compounds was investigated by a method using restriction enzymes and a specially designed 1.5 kb DNA fragment. Kokusaginine showed inhibition against all of the 16 restriction enzymes. Haplopine showed a similar inhibition pattern but the binding activity against Asc I and Sma I with restriction sequences consisting only of G and C was very weak. Skimmianine showed binding activity against Xba I, BciV I, Sal I, Pst I, Sph I and Hind III, but very weak or no activity was found for the other restriction enzymes. A pyranoquinolone, flindersine, showed no activity against any of the restriction enzymes. Photo-activated DNA binding activity of furoquinolines was therefore in the order of kokusaginine > haplopine > skimmianine, which was the same order as their photo-activated antimicrobial activity against S. aureus. Therefore, it was concluded that DNA is one of the cellular targets for the furoquinolines to exert their biological activities, similar to psoralens. However, because flindersine showed photo-activated antimicrobial activity against S. aureus but did not show photo-activated DNA binding activity, it is clear that there are other cellular target components for this compound to exert photo-toxic activity.
Found
Nothing found, try to update filter.
Found
Nothing found, try to update filter.
Top-30
Journals
|
1
2
3
4
5
|
|
|
Journal of Heterocyclic Chemistry
5 publications, 11.11%
|
|
|
RSC Advances
3 publications, 6.67%
|
|
|
European Journal of Medicinal Chemistry
2 publications, 4.44%
|
|
|
Bioorganic Chemistry
2 publications, 4.44%
|
|
|
Tetrahedron Letters
2 publications, 4.44%
|
|
|
Current Traditional Medicine
1 publication, 2.22%
|
|
|
Journal of Chemical Research
1 publication, 2.22%
|
|
|
Chemistry of Heterocyclic Compounds
1 publication, 2.22%
|
|
|
Research on Chemical Intermediates
1 publication, 2.22%
|
|
|
Journal of Molecular Structure
1 publication, 2.22%
|
|
|
Monatshefte fur Chemie
1 publication, 2.22%
|
|
|
Bulletin of the Korean Chemical Society
1 publication, 2.22%
|
|
|
Phytochemistry
1 publication, 2.22%
|
|
|
Bioorganic and Medicinal Chemistry
1 publication, 2.22%
|
|
|
International Journal of Antimicrobial Agents
1 publication, 2.22%
|
|
|
Medicinal Research Reviews
1 publication, 2.22%
|
|
|
ChemMedChem
1 publication, 2.22%
|
|
|
Journal of Physical Chemistry A
1 publication, 2.22%
|
|
|
Journal of Physical Chemistry B
1 publication, 2.22%
|
|
|
Journal of Medicinal Chemistry
1 publication, 2.22%
|
|
|
ACS Sustainable Chemistry and Engineering
1 publication, 2.22%
|
|
|
Journal of Organic Chemistry
1 publication, 2.22%
|
|
|
Natural Product Reports
1 publication, 2.22%
|
|
|
Green Chemistry
1 publication, 2.22%
|
|
|
Organic and Biomolecular Chemistry
1 publication, 2.22%
|
|
|
Synthetic Communications
1 publication, 2.22%
|
|
|
Polycyclic Aromatic Compounds
1 publication, 2.22%
|
|
|
Open Journal of Medicinal Chemistry
1 publication, 2.22%
|
|
|
Synlett
1 publication, 2.22%
|
|
|
1
2
3
4
5
|
Publishers
|
2
4
6
8
10
12
|
|
|
Elsevier
11 publications, 24.44%
|
|
|
Wiley
9 publications, 20%
|
|
|
Royal Society of Chemistry (RSC)
6 publications, 13.33%
|
|
|
American Chemical Society (ACS)
5 publications, 11.11%
|
|
|
Springer Nature
4 publications, 8.89%
|
|
|
Taylor & Francis
2 publications, 4.44%
|
|
|
MDPI
2 publications, 4.44%
|
|
|
Bentham Science Publishers Ltd.
1 publication, 2.22%
|
|
|
SAGE
1 publication, 2.22%
|
|
|
Scientific Research Publishing
1 publication, 2.22%
|
|
|
Georg Thieme Verlag KG
1 publication, 2.22%
|
|
|
2
4
6
8
10
12
|
- We do not take into account publications without a DOI.
- Statistics recalculated weekly.
Are you a researcher?
Create a profile to get free access to personal recommendations for colleagues and new articles.
Metrics
45
Total citations:
45
Citations from 2025:
0
Cite this
GOST |
RIS |
BibTex |
MLA
Cite this
GOST
Copy
Hanawa F. Photo-Activated DNA Binding and Antimicrobial Activities of Furoquinoline and Pyranoquinolone Alkaloids from Rutaceae // Planta Medica. 2004. Vol. 70. No. 6. pp. 531-535.
GOST all authors (up to 50)
Copy
Hanawa F. Photo-Activated DNA Binding and Antimicrobial Activities of Furoquinoline and Pyranoquinolone Alkaloids from Rutaceae // Planta Medica. 2004. Vol. 70. No. 6. pp. 531-535.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1055/s-2004-827153
UR - https://doi.org/10.1055/s-2004-827153
TI - Photo-Activated DNA Binding and Antimicrobial Activities of Furoquinoline and Pyranoquinolone Alkaloids from Rutaceae
T2 - Planta Medica
AU - Hanawa, Fujinori
PY - 2004
DA - 2004/06/01
PB - Georg Thieme Verlag KG
SP - 531-535
IS - 6
VL - 70
PMID - 15229804
SN - 0032-0943
SN - 1439-0221
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2004_Hanawa,
author = {Fujinori Hanawa},
title = {Photo-Activated DNA Binding and Antimicrobial Activities of Furoquinoline and Pyranoquinolone Alkaloids from Rutaceae},
journal = {Planta Medica},
year = {2004},
volume = {70},
publisher = {Georg Thieme Verlag KG},
month = {jun},
url = {https://doi.org/10.1055/s-2004-827153},
number = {6},
pages = {531--535},
doi = {10.1055/s-2004-827153}
}
Cite this
MLA
Copy
Hanawa, Fujinori. “Photo-Activated DNA Binding and Antimicrobial Activities of Furoquinoline and Pyranoquinolone Alkaloids from Rutaceae.” Planta Medica, vol. 70, no. 6, Jun. 2004, pp. 531-535. https://doi.org/10.1055/s-2004-827153.