Development and application of the cytopathic model of Hantaan viruses

We have developed a cytopathic model using an MTT test for viruses Hantaan 76-118 and for Puumala 967. Our research has shown that ribavirin is not active with the viruses under study, while being fairly toxic to CC50 20 µM. Triazavirin was active for Hantaan 76-118 in a dose of IC50 14±3 µM, and for Puumala 967 IC50 12±3 µM. The toxicity of Triazavirin was 368±18 µM. The selectivity indices of SI of this agent with regard to these viruses were 26 and 30, respectively.