Development and application of the cytopathic model of Hantaan viruses

Publication type: Proceedings Article
Publication date: 2021-11-19
AIP Publishing
SJR: 0.153
CiteScore: 0.5
Impact factor: —
ISSN: 0094243X, 15517616
Abstract
We have developed a cytopathic model using an MTT test for viruses Hantaan 76-118 and for Puumala 967. Our research has shown that ribavirin is not active with the viruses under study, while being fairly toxic to CC50 20 µM. Triazavirin was active for Hantaan 76-118 in a dose of IC50 14±3 µM, and for Puumala 967 IC50 12±3 µM. The toxicity of Triazavirin was 368±18 µM. The selectivity indices of SI of this agent with regard to these viruses were 26 and 30, respectively.
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Yarovaya O. I. et al. Development and application of the cytopathic model of Hantaan viruses // AIP Conference Proceedings. 2021.
GOST all authors (up to 50) Copy
Yarovaya O. I., Zaykovskaya A. V., Kovaleva K., Pyankov O., Salakhutdinov N. Development and application of the cytopathic model of Hantaan viruses // AIP Conference Proceedings. 2021.
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RIS Copy
TY - CPAPER
DO - 10.1063/5.0069403
UR - https://doi.org/10.1063/5.0069403
TI - Development and application of the cytopathic model of Hantaan viruses
T2 - AIP Conference Proceedings
AU - Yarovaya, Olga I.
AU - Zaykovskaya, Anna V.
AU - Kovaleva, Kseniya
AU - Pyankov, Oleg
AU - Salakhutdinov, Nariman
PY - 2021
DA - 2021/11/19
PB - AIP Publishing
SN - 0094-243X
SN - 1551-7616
ER -
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BibTex (up to 50 authors) Copy
@inproceedings{2021_Yarovaya,
author = {Olga I. Yarovaya and Anna V. Zaykovskaya and Kseniya Kovaleva and Oleg Pyankov and Nariman Salakhutdinov},
title = {Development and application of the cytopathic model of Hantaan viruses},
year = {2021},
month = {nov},
publisher = {AIP Publishing}
}