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Small synthetic molecules with antiglycation activity. Structure–activity relationship
Тип публикации: Journal Article
Дата публикации: 2022-07-01
SCImago Q1
WOS Q1
БС1
SJR: 0.955
CiteScore: 10.5
Impact factor: 7.1
ISSN: 0036021X, 14684837
General Chemistry
Краткое описание
The accumulation of advanced glycation end products (AGEs) is currently considered as one of the key factors in aging processes, the pathogenesis of late complications of diabetes mellitus, cancer and neurodegenerative diseases. This review is devoted to small synthetic molecules with antiglycation activity, i.e., compounds with the ability to inhibit AGE formation. Molecules with antiglycation activity in the low micromolar range (<10 μM), primarily fused heterocyclic systems containing oxygen or nitrogen as heteroatoms and (thio)ureas, have been discovered to date. The known scaffolds with antiglycation activity are analyzed, structural modifications to enhance antiglycation abilities are highlighted and the structure–activity relationships are discussed.
The bibliography includes 125 references.
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Savateev K. V., Спасов А. А., Rusinov V. L. Small synthetic molecules with antiglycation activity. Structure–activity relationship // Russian Chemical Reviews. 2022. Vol. 91. No. 6. p. RCR5041.
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Savateev K. V., Спасов А. А., Rusinov V. L. Small synthetic molecules with antiglycation activity. Structure–activity relationship // Russian Chemical Reviews. 2022. Vol. 91. No. 6. p. RCR5041.
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TY - JOUR
DO - 10.1070/RCR5041
UR - https://doi.org/10.1070/RCR5041
TI - Small synthetic molecules with antiglycation activity. Structure–activity relationship
T2 - Russian Chemical Reviews
AU - Savateev, Konstantin V
AU - Спасов, А. А.
AU - Rusinov, Vladimir L
PY - 2022
DA - 2022/07/01
PB - Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii
SP - RCR5041
IS - 6
VL - 91
SN - 0036-021X
SN - 1468-4837
ER -
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BibTex (до 50 авторов)
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@article{2022_Savateev,
author = {Konstantin V Savateev and А. А. Спасов and Vladimir L Rusinov},
title = {Small synthetic molecules with antiglycation activity. Structure–activity relationship},
journal = {Russian Chemical Reviews},
year = {2022},
volume = {91},
publisher = {Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii},
month = {jul},
url = {https://doi.org/10.1070/RCR5041},
number = {6},
pages = {RCR5041},
doi = {10.1070/RCR5041}
}
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MLA
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Savateev, Konstantin V., et al. “Small synthetic molecules with antiglycation activity. Structure–activity relationship.” Russian Chemical Reviews, vol. 91, no. 6, Jul. 2022, p. RCR5041. https://doi.org/10.1070/RCR5041.
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