Open Access
,
volume 112
,
issue 17
Molecular recognition of human ephrinB2 cell surface receptor by an emergent African henipavirus
Benhur Lee
1
,
Olivier Pernet
2
,
Asim A. Ahmed
3
,
Antra Zeltina
4
,
Shannon M Beaty
1
,
Thomas A. Bowden
4
Publication type: Journal Article
Publication date: 2015-03-30
scimago Q1
wos Q1
SJR: 3.414
CiteScore: 16.5
Impact factor: 9.1
ISSN: 00278424, 10916490
PubMed ID:
25825759
Multidisciplinary
Abstract
Significance
African henipaviruses (HNVs) may be responsible for the misdiagnosis of encephalitis-associated outbreaks of malaria. Host-cell infection by an African HNV relies on the initial interaction between a virally encoded surface glycoprotein and a host-cell receptor. Here, we provide a structural description of how a bat-borne Ghanaian HNV hijacks human ephrinB2 to facilitate cross-species transmission. We demonstrate that, although the Ghanian HNV is sequence dissimilar (<30% sequence identity) and displays a receptor-binding scaffold that differs significantly in structure to pathogenic HNV relatives from Asia, it adopts a nearly identical primary ephrinB2 binding mode. These data provide a molecular-level explanation for previously observed spillover of African HNVs into human populations.
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Metrics
58
Total citations:
58
Citations from 2024:
14
(24.14%)
Cite this
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GOST
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Lee B. et al. Molecular recognition of human ephrinB2 cell surface receptor by an emergent African henipavirus // Proceedings of the National Academy of Sciences of the United States of America. 2015. Vol. 112. No. 17.
GOST all authors (up to 50)
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Lee B., Pernet O., Ahmed A. A., Zeltina A., Beaty S. M., Bowden T. Molecular recognition of human ephrinB2 cell surface receptor by an emergent African henipavirus // Proceedings of the National Academy of Sciences of the United States of America. 2015. Vol. 112. No. 17.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1073/pnas.1501690112
UR - https://doi.org/10.1073/pnas.1501690112
TI - Molecular recognition of human ephrinB2 cell surface receptor by an emergent African henipavirus
T2 - Proceedings of the National Academy of Sciences of the United States of America
AU - Lee, Benhur
AU - Pernet, Olivier
AU - Ahmed, Asim A.
AU - Zeltina, Antra
AU - Beaty, Shannon M
AU - Bowden, Thomas A.
PY - 2015
DA - 2015/03/30
PB - Proceedings of the National Academy of Sciences (PNAS)
IS - 17
VL - 112
PMID - 25825759
SN - 0027-8424
SN - 1091-6490
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2015_Lee,
author = {Benhur Lee and Olivier Pernet and Asim A. Ahmed and Antra Zeltina and Shannon M Beaty and Thomas A. Bowden},
title = {Molecular recognition of human ephrinB2 cell surface receptor by an emergent African henipavirus},
journal = {Proceedings of the National Academy of Sciences of the United States of America},
year = {2015},
volume = {112},
publisher = {Proceedings of the National Academy of Sciences (PNAS)},
month = {mar},
url = {https://doi.org/10.1073/pnas.1501690112},
number = {17},
doi = {10.1073/pnas.1501690112}
}