Open Access
,
volume 117
,
issue 18
,
pages 9840-9850
Moderation of mitochondrial respiration mitigates metabolic syndrome of aging
Fa-Qin Jiang
1
,
Ramouna Voshtani
2
,
Xinxian Deng
1
,
Yixue Qiao
1
,
Faqin Jiang
1
,
James P. Collman
3
,
Lei Fu
1
Publication type: Journal Article
Publication date: 2020-04-17
scimago Q1
wos Q1
SJR: 3.414
CiteScore: 16.5
Impact factor: 9.1
ISSN: 00278424, 10916490
PubMed ID:
32303655
Multidisciplinary
Abstract
Significance
The efforts toward minimizing oxidative stress and maintaining mitochondrial energy metabolism for promoted healthy aging are at the forefront of current research on aging. We have characterized a treatment that, by reversible inhibition of mitochondrial respiration in mice through cytochrome c oxidase (CcO), markedly improves mitochondrial bioenergetics and delays the lead health concerns associated with aging in mice. We demonstrated that chronic moderate inhibition of CcO reduces ATP synthesis, promotes mitochondrial biogenesis and mitophagy, subsequently decreases ROS production and mitochondrial decay, and rectifies vital cellular energy metabolism regulators, thus, effectively refining energy homeostasis and curbing obesity and glucose irregularities linked to aging.
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Metrics
53
Total citations:
53
Citations from 2024:
12
(22.64%)
Cite this
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RIS |
BibTex |
MLA
Cite this
GOST
Copy
Jiang F. et al. Moderation of mitochondrial respiration mitigates metabolic syndrome of aging // Proceedings of the National Academy of Sciences of the United States of America. 2020. Vol. 117. No. 18. pp. 9840-9850.
GOST all authors (up to 50)
Copy
Jiang F., Voshtani R., Deng X., Qiao Y., Jiang F., Collman J. P., Fu L. Moderation of mitochondrial respiration mitigates metabolic syndrome of aging // Proceedings of the National Academy of Sciences of the United States of America. 2020. Vol. 117. No. 18. pp. 9840-9850.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1073/pnas.1917948117
UR - https://doi.org/10.1073/pnas.1917948117
TI - Moderation of mitochondrial respiration mitigates metabolic syndrome of aging
T2 - Proceedings of the National Academy of Sciences of the United States of America
AU - Jiang, Fa-Qin
AU - Voshtani, Ramouna
AU - Deng, Xinxian
AU - Qiao, Yixue
AU - Jiang, Faqin
AU - Collman, James P.
AU - Fu, Lei
PY - 2020
DA - 2020/04/17
PB - Proceedings of the National Academy of Sciences (PNAS)
SP - 9840-9850
IS - 18
VL - 117
PMID - 32303655
SN - 0027-8424
SN - 1091-6490
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2020_Jiang,
author = {Fa-Qin Jiang and Ramouna Voshtani and Xinxian Deng and Yixue Qiao and Faqin Jiang and James P. Collman and Lei Fu},
title = {Moderation of mitochondrial respiration mitigates metabolic syndrome of aging},
journal = {Proceedings of the National Academy of Sciences of the United States of America},
year = {2020},
volume = {117},
publisher = {Proceedings of the National Academy of Sciences (PNAS)},
month = {apr},
url = {https://doi.org/10.1073/pnas.1917948117},
number = {18},
pages = {9840--9850},
doi = {10.1073/pnas.1917948117}
}
Cite this
MLA
Copy
Jiang, Fa-Qin, et al. “Moderation of mitochondrial respiration mitigates metabolic syndrome of aging.” Proceedings of the National Academy of Sciences of the United States of America, vol. 117, no. 18, Apr. 2020, pp. 9840-9850. https://doi.org/10.1073/pnas.1917948117.