Open Access
,
volume 117
,
issue 7
,
pages 3848-3857
Positive allosteric modulation of indoleamine 2,3-dioxygenase 1 restrains neuroinflammation
Giada Mondanelli
1
,
Alice Coletti
2
,
Francesco Antonio Greco
2
,
Maria Teresa Pallotta
1
,
Ciriana Orabona
1
,
Alberta Iacono
1
,
Maria Laura Belladonna
1
,
Elisa Albini
1, 2
,
Eleonora Panfili
1
,
Francesca Fallarino
1
,
Marco Gargaro
1
,
Giorgia Manni
1
,
Davide Matino
1
,
Agostinho Carvalho
3, 4
,
Cristina Cunha
3, 4
,
Patricia Maciel
3, 4
,
Massimiliano Di Filippo
5
,
Lorenzo Gaetani
5
,
Roberta Bianchi
1
,
Carmine Vacca
1
,
Ioana Maria Iamandii
1
,
Elisa Proietti
1
,
Francesca Boscia
6
,
Lucio Annunziato
6
,
Maikel Peppelenbosch
7
,
PAOLO PUCCETTI
1
,
Paolo Calabresi
5
,
Antonio Macchiarulo
2
,
L Santambrogio
8, 9, 10
,
Claudia Volpi
1
,
Ursula Grohmann
1, 11
4
ICVS/3B’s–PT Government Associate Laboratory, 4704-553 Braga/Guimarães, Portugal;
|
7
Department of Gastroenterology and Hepatology, Erasmus Medical Centre–University Medical Centre Rotterdam, 3015 GD Rotterdam, The Netherlands;
|
Publication type: Journal Article
Publication date: 2020-02-05
scimago Q1
wos Q1
SJR: 3.414
CiteScore: 16.5
Impact factor: 9.1
ISSN: 00278424, 10916490
PubMed ID:
32024760
Multidisciplinary
Abstract
Significance
Indoleamine 2,3-dioxygenase 1 (IDO1) is an immunoregulatory enzyme that transforms tryptophan into kynurenine, an endogenous agonist of the aryl hydrocarbon receptor (AhR) whose activation sustains IDO1 expression and activity over the long term in dendritic cells (DCs). Here we found that N -acetylserotonin (NAS), a tryptophan metabolite produced along the serotonin pathway, acts as a positive allosteric modulator (PAM) of IDO1 and thus increases kynurenine-mediated AhR activation in DCs. NAS effects on IDO1 translated into protection of mice from neuroinflammation and reinstallment of physiologic IDO1 activity in peripheral blood mononuclear cells from patients with relapsing-remitting multiple sclerosis.
Found
Nothing found, try to update filter.
Found
Nothing found, try to update filter.
Top-30
Journals
|
1
2
3
4
|
|
|
Frontiers in Immunology
4 publications, 5.41%
|
|
|
International Journal of Molecular Sciences
3 publications, 4.05%
|
|
|
Current Opinion in Immunology
3 publications, 4.05%
|
|
|
ChemMedChem
3 publications, 4.05%
|
|
|
International Journal of Tryptophan Research
2 publications, 2.7%
|
|
|
Cells
2 publications, 2.7%
|
|
|
Cancers
2 publications, 2.7%
|
|
|
Frontiers in Neuroscience
2 publications, 2.7%
|
|
|
Nature Communications
2 publications, 2.7%
|
|
|
Brain Behavior & Immunity - Health
2 publications, 2.7%
|
|
|
European Journal of Pharmacology
2 publications, 2.7%
|
|
|
Proceedings of the National Academy of Sciences of the United States of America
2 publications, 2.7%
|
|
|
International Immunopharmacology
2 publications, 2.7%
|
|
|
Cell Death and Disease
1 publication, 1.35%
|
|
|
Molecular Pharmacology
1 publication, 1.35%
|
|
|
Biomolecules
1 publication, 1.35%
|
|
|
Nutrients
1 publication, 1.35%
|
|
|
Clinical Oral Investigations
1 publication, 1.35%
|
|
|
Neuroscience
1 publication, 1.35%
|
|
|
Journal of Neuroinflammation
1 publication, 1.35%
|
|
|
Free Radical Biology and Medicine
1 publication, 1.35%
|
|
|
Trends in Immunology
1 publication, 1.35%
|
|
|
Journal of Autoimmunity
1 publication, 1.35%
|
|
|
Biochimica et Biophysica Acta - Molecular Basis of Disease
1 publication, 1.35%
|
|
|
Bioorganic Chemistry
1 publication, 1.35%
|
|
|
Pharmacology and Therapeutics
1 publication, 1.35%
|
|
|
Trends in Molecular Medicine
1 publication, 1.35%
|
|
|
FEBS Journal
1 publication, 1.35%
|
|
|
Journal of Clinical Laboratory Analysis
1 publication, 1.35%
|
|
|
1
2
3
4
|
Publishers
|
5
10
15
20
25
|
|
|
Elsevier
23 publications, 31.08%
|
|
|
MDPI
9 publications, 12.16%
|
|
|
Frontiers Media S.A.
9 publications, 12.16%
|
|
|
Springer Nature
8 publications, 10.81%
|
|
|
Wiley
6 publications, 8.11%
|
|
|
SAGE
2 publications, 2.7%
|
|
|
American Chemical Society (ACS)
2 publications, 2.7%
|
|
|
Proceedings of the National Academy of Sciences (PNAS)
2 publications, 2.7%
|
|
|
American Society for Pharmacology and Experimental Therapeutics
1 publication, 1.35%
|
|
|
BMJ
1 publication, 1.35%
|
|
|
IntechOpen
1 publication, 1.35%
|
|
|
Hindawi Limited
1 publication, 1.35%
|
|
|
Beijing University of Chinese Medicine
1 publication, 1.35%
|
|
|
eLife Sciences Publications
1 publication, 1.35%
|
|
|
Cold Spring Harbor Laboratory
1 publication, 1.35%
|
|
|
Royal Society of Chemistry (RSC)
1 publication, 1.35%
|
|
|
IMR Press
1 publication, 1.35%
|
|
|
Taylor & Francis
1 publication, 1.35%
|
|
|
Ankara University
1 publication, 1.35%
|
|
|
S. Karger AG
1 publication, 1.35%
|
|
|
Apex Publishing
1 publication, 1.35%
|
|
|
5
10
15
20
25
|
- We do not take into account publications without a DOI.
- Statistics recalculated weekly.
Are you a researcher?
Create a profile to get free access to personal recommendations for colleagues and new articles.
Metrics
74
Total citations:
74
Citations from 2024:
20
(27.02%)
Cite this
GOST |
RIS |
BibTex |
MLA
Cite this
GOST
Copy
Mondanelli G. et al. Positive allosteric modulation of indoleamine 2,3-dioxygenase 1 restrains neuroinflammation // Proceedings of the National Academy of Sciences of the United States of America. 2020. Vol. 117. No. 7. pp. 3848-3857.
GOST all authors (up to 50)
Copy
Mondanelli G., Coletti A., Greco F. A., Pallotta M. T., Orabona C., Iacono A., Belladonna M. L., Albini E., Panfili E., Fallarino F., Gargaro M., Manni G., Matino D., Carvalho A., Cunha C., Maciel P., Di Filippo M., Gaetani L., Bianchi R., Vacca C., Iamandii I. M., Proietti E., Boscia F., Annunziato L., Peppelenbosch M., PUCCETTI P., Calabresi P., Macchiarulo A., Santambrogio L., Volpi C., Grohmann U. Positive allosteric modulation of indoleamine 2,3-dioxygenase 1 restrains neuroinflammation // Proceedings of the National Academy of Sciences of the United States of America. 2020. Vol. 117. No. 7. pp. 3848-3857.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1073/pnas.1918215117
UR - https://doi.org/10.1073/pnas.1918215117
TI - Positive allosteric modulation of indoleamine 2,3-dioxygenase 1 restrains neuroinflammation
T2 - Proceedings of the National Academy of Sciences of the United States of America
AU - Mondanelli, Giada
AU - Coletti, Alice
AU - Greco, Francesco Antonio
AU - Pallotta, Maria Teresa
AU - Orabona, Ciriana
AU - Iacono, Alberta
AU - Belladonna, Maria Laura
AU - Albini, Elisa
AU - Panfili, Eleonora
AU - Fallarino, Francesca
AU - Gargaro, Marco
AU - Manni, Giorgia
AU - Matino, Davide
AU - Carvalho, Agostinho
AU - Cunha, Cristina
AU - Maciel, Patricia
AU - Di Filippo, Massimiliano
AU - Gaetani, Lorenzo
AU - Bianchi, Roberta
AU - Vacca, Carmine
AU - Iamandii, Ioana Maria
AU - Proietti, Elisa
AU - Boscia, Francesca
AU - Annunziato, Lucio
AU - Peppelenbosch, Maikel
AU - PUCCETTI, PAOLO
AU - Calabresi, Paolo
AU - Macchiarulo, Antonio
AU - Santambrogio, L
AU - Volpi, Claudia
AU - Grohmann, Ursula
PY - 2020
DA - 2020/02/05
PB - Proceedings of the National Academy of Sciences (PNAS)
SP - 3848-3857
IS - 7
VL - 117
PMID - 32024760
SN - 0027-8424
SN - 1091-6490
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2020_Mondanelli,
author = {Giada Mondanelli and Alice Coletti and Francesco Antonio Greco and Maria Teresa Pallotta and Ciriana Orabona and Alberta Iacono and Maria Laura Belladonna and Elisa Albini and Eleonora Panfili and Francesca Fallarino and Marco Gargaro and Giorgia Manni and Davide Matino and Agostinho Carvalho and Cristina Cunha and Patricia Maciel and Massimiliano Di Filippo and Lorenzo Gaetani and Roberta Bianchi and Carmine Vacca and Ioana Maria Iamandii and Elisa Proietti and Francesca Boscia and Lucio Annunziato and Maikel Peppelenbosch and PAOLO PUCCETTI and Paolo Calabresi and Antonio Macchiarulo and L Santambrogio and Claudia Volpi and Ursula Grohmann},
title = {Positive allosteric modulation of indoleamine 2,3-dioxygenase 1 restrains neuroinflammation},
journal = {Proceedings of the National Academy of Sciences of the United States of America},
year = {2020},
volume = {117},
publisher = {Proceedings of the National Academy of Sciences (PNAS)},
month = {feb},
url = {https://doi.org/10.1073/pnas.1918215117},
number = {7},
pages = {3848--3857},
doi = {10.1073/pnas.1918215117}
}
Cite this
MLA
Copy
Mondanelli, Giada, et al. “Positive allosteric modulation of indoleamine 2,3-dioxygenase 1 restrains neuroinflammation.” Proceedings of the National Academy of Sciences of the United States of America, vol. 117, no. 7, Feb. 2020, pp. 3848-3857. https://doi.org/10.1073/pnas.1918215117.