Open Access
,
volume 117
,
issue 7
,
pages 3728-3737
Combining microenvironment normalization strategies to improve cancer immunotherapy
Fotios Mpekris
1
,
Chrysovalantis Voutouri
1
,
James W Baish
2
,
Dan G. Duda
3
,
Lance L. Munn
3
,
Rakesh Kumar Jain
3
Publication type: Journal Article
Publication date: 2020-02-03
scimago Q1
wos Q1
SJR: 3.414
CiteScore: 16.5
Impact factor: 9.1
ISSN: 00278424, 10916490
PubMed ID:
32015113
Multidisciplinary
Abstract
Significance
Immunotherapy has changed the standard of care in cancer treatment, but an estimated 87% of patients currently do not derive long-term benefit from immune checkpoint blocker monotherapy. Therefore, new therapeutic strategies are needed to improve the response rates in patients who are resistant to immune checkpoint inhibition. We have developed a mathematical framework to determine how tumor microenvironment normalization strategies—specifically, vascular and stroma normalization—might improve immunotherapy efficacy. By incorporating complex interactions among various types of cancer cells, immune cells, stromal cells, and the vasculature, as well as physical mechanisms, we provide guidelines for designing effective combinatorial therapeutic strategies and point out areas for future investigation.
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Metrics
206
Total citations:
206
Citations from 2024:
60
(29.13%)
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GOST
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Mpekris F. et al. Combining microenvironment normalization strategies to improve cancer immunotherapy // Proceedings of the National Academy of Sciences of the United States of America. 2020. Vol. 117. No. 7. pp. 3728-3737.
GOST all authors (up to 50)
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Mpekris F., Voutouri C., Baish J. W., Duda D. G., Munn L. L., Stylianopoulos T., Jain R. K. Combining microenvironment normalization strategies to improve cancer immunotherapy // Proceedings of the National Academy of Sciences of the United States of America. 2020. Vol. 117. No. 7. pp. 3728-3737.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1073/pnas.1919764117
UR - https://doi.org/10.1073/pnas.1919764117
TI - Combining microenvironment normalization strategies to improve cancer immunotherapy
T2 - Proceedings of the National Academy of Sciences of the United States of America
AU - Mpekris, Fotios
AU - Voutouri, Chrysovalantis
AU - Baish, James W
AU - Duda, Dan G.
AU - Munn, Lance L.
AU - Stylianopoulos, Triantafyllos
AU - Jain, Rakesh Kumar
PY - 2020
DA - 2020/02/03
PB - Proceedings of the National Academy of Sciences (PNAS)
SP - 3728-3737
IS - 7
VL - 117
PMID - 32015113
SN - 0027-8424
SN - 1091-6490
ER -
Cite this
BibTex (up to 50 authors)
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@article{2020_Mpekris,
author = {Fotios Mpekris and Chrysovalantis Voutouri and James W Baish and Dan G. Duda and Lance L. Munn and Triantafyllos Stylianopoulos and Rakesh Kumar Jain},
title = {Combining microenvironment normalization strategies to improve cancer immunotherapy},
journal = {Proceedings of the National Academy of Sciences of the United States of America},
year = {2020},
volume = {117},
publisher = {Proceedings of the National Academy of Sciences (PNAS)},
month = {feb},
url = {https://doi.org/10.1073/pnas.1919764117},
number = {7},
pages = {3728--3737},
doi = {10.1073/pnas.1919764117}
}
Cite this
MLA
Copy
Mpekris, Fotios, et al. “Combining microenvironment normalization strategies to improve cancer immunotherapy.” Proceedings of the National Academy of Sciences of the United States of America, vol. 117, no. 7, Feb. 2020, pp. 3728-3737. https://doi.org/10.1073/pnas.1919764117.