Open Access
,
volume 117
,
issue 45
,
pages 28316-28327
Harnessing 64 Cu/ 67 Cu for a theranostic approach to pretargeted radioimmunotherapy
Outi Keinänen
1, 2
,
Kimberly Fung
1, 3
,
James M. Brennan
1
,
Nicholas Zia
4
,
Matt Harris
5
,
Ellen M. van Dam
5
,
Colin Biggin
5
,
Amos Hedt
5
,
Jon Stoner
6
,
Paul S. Donnelly
4
,
Jason J. Lewis
2, 7, 8
,
Brian M. Zeglis
1, 2, 3, 7
3
5
Clarity Pharmaceuticals, Sydney, NSW 2042, Australia;
|
Publication type: Journal Article
Publication date: 2020-10-26
scimago Q1
wos Q1
SJR: 3.414
CiteScore: 16.5
Impact factor: 9.1
ISSN: 00278424, 10916490
PubMed ID:
33106429
Multidisciplinary
Abstract
Significance
Radioimmunotherapy is predicated on harnessing the exquisite specificity of antibodies to deliver cytotoxic radiation to tumors. Yet the long circulation time of radioimmunoconjugates leads to high radiation doses to healthy tissues. Pretargeted radioimmunotherapy (PRIT) circumvents this problem by decoupling the antibody and radionuclide, injecting the former prior to the latter, and empowering the two components to combine at the tumor. We have leveraged bioorthogonal click chemistry, a colorectal cancer-targeting antibody, and a pair radioligands bearing radioisotopes of copper—positron-emitting copper-64 and beta particle-emitting copper-67—to create a pretargeting system that enables both theranostic positron emission tomography and PRIT. We believe that the incorporation of theranostic imaging into PRIT regimens could be instrumental in the clinical success of the modality.
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Total citations:
99
Citations from 2024:
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(37%)
Cite this
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MLA
Cite this
GOST
Copy
Keinänen O. et al. Harnessing 64 Cu/ 67 Cu for a theranostic approach to pretargeted radioimmunotherapy // Proceedings of the National Academy of Sciences of the United States of America. 2020. Vol. 117. No. 45. pp. 28316-28327.
GOST all authors (up to 50)
Copy
Keinänen O., Fung K., Brennan J. M., Zia N., Harris M., van Dam E. M., Biggin C., Hedt A., Stoner J., Donnelly P. S., Lewis J. J., Zeglis B. M. Harnessing 64 Cu/ 67 Cu for a theranostic approach to pretargeted radioimmunotherapy // Proceedings of the National Academy of Sciences of the United States of America. 2020. Vol. 117. No. 45. pp. 28316-28327.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1073/pnas.2009960117
UR - https://doi.org/10.1073/pnas.2009960117
TI - Harnessing 64 Cu/ 67 Cu for a theranostic approach to pretargeted radioimmunotherapy
T2 - Proceedings of the National Academy of Sciences of the United States of America
AU - Keinänen, Outi
AU - Fung, Kimberly
AU - Brennan, James M.
AU - Zia, Nicholas
AU - Harris, Matt
AU - van Dam, Ellen M.
AU - Biggin, Colin
AU - Hedt, Amos
AU - Stoner, Jon
AU - Donnelly, Paul S.
AU - Lewis, Jason J.
AU - Zeglis, Brian M.
PY - 2020
DA - 2020/10/26
PB - Proceedings of the National Academy of Sciences (PNAS)
SP - 28316-28327
IS - 45
VL - 117
PMID - 33106429
SN - 0027-8424
SN - 1091-6490
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2020_Keinänen,
author = {Outi Keinänen and Kimberly Fung and James M. Brennan and Nicholas Zia and Matt Harris and Ellen M. van Dam and Colin Biggin and Amos Hedt and Jon Stoner and Paul S. Donnelly and Jason J. Lewis and Brian M. Zeglis},
title = {Harnessing 64 Cu/ 67 Cu for a theranostic approach to pretargeted radioimmunotherapy},
journal = {Proceedings of the National Academy of Sciences of the United States of America},
year = {2020},
volume = {117},
publisher = {Proceedings of the National Academy of Sciences (PNAS)},
month = {oct},
url = {https://doi.org/10.1073/pnas.2009960117},
number = {45},
pages = {28316--28327},
doi = {10.1073/pnas.2009960117}
}
Cite this
MLA
Copy
Keinänen, Outi, et al. “Harnessing 64 Cu/ 67 Cu for a theranostic approach to pretargeted radioimmunotherapy.” Proceedings of the National Academy of Sciences of the United States of America, vol. 117, no. 45, Oct. 2020, pp. 28316-28327. https://doi.org/10.1073/pnas.2009960117.