Open Access

Proceedings of the National Academy of Sciences (PNAS)

Proceedings of the National Academy of Sciences of the United States of America

, volume 117 , issue 36 , pages 22311-22322

Broad host range of SARS-CoV-2 predicted by comparative and structural analysis of ACE2 in vertebrates

Joana Damas ¹

Graham M. Hughes ²

Kathleen C Keough ^{3, 4}

Corrie A. Painter ⁵

Nicole S. Persky ⁶

Marco Corbo ¹

Michael Edward Hiller ^{7, 8, 9}

Klaus-Peter Koepfli ¹⁰

Andreas Pfenning ¹¹

Huabin Zhao ^{12, 13}

Diane P. Genereux ¹⁴

Ross Swofford ¹⁴

Katherine Pollard ^{4, 15, 16}

Oliver A. Ryder ^{17, 18}

Martin T Nweeia ^{19, 20, 21}

Kerstin Lindblad-Toh ^{14, 22}

Emma C. Teeling ²

E.K. Karlsson ^{14, 23, 24}

HARRIS A. LEWIN ^{1, 25, 26}

Hide authors affiliations Show authors affiliations: 26 affiliations

The Genome Center, University of California, Davis, CA 95616; |

School of Biology and Environmental Science, University College Dublin, Belfield, Dublin 4, Ireland; |

Graduate Program in Pharmaceutical Sciences and Pharmacogenomics, Quantitative Biosciences Consortium, University of California, San Francisco, CA 94117; |

⁴

Gladstone Institute of Data Science and Biotechnology, San Francisco, CA 94158; |

⁵

Cancer Program, Broad Institute of MIT and Harvard, Cambridge, MA 02142; |

⁶

Genetic Perturbation Platform, Broad Institute of MIT and Harvard, Cambridge, MA 02142; |

⁷

Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany; |

⁸

Max Planck Institute for the Physics of Complex Systems, 01187 Dresden, Germany; |

⁹

Center for Systems Biology Dresden, 01307 Dresden, Germany; |

¹⁰

Center for Species Survival, Smithsonian Conservation Biology Institute, National Zoological Park, Front Royal, VA 22630; |

¹¹

Department of Computational Biology, School of Computer Science, Carnegie Mellon University, Pittsburgh, PA 15213; |

¹²

Department of Ecology, Tibetan Centre for Ecology and Conservation at WHU-TU, Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan 430072, China; |

¹³

College of Science, Tibet University, Lhasa 850000, China; |

¹⁴

Broad Institute of MIT and Harvard, Cambridge, MA 02142; |

¹⁵

Department of Epidemiology & Biostatistics, Institute for Computational Health Sciences, and Institute for Human Genetics, University of California, San Francisco, CA 94158; |

¹⁶

Chan Zuckerberg Biohub, San Francisco, CA 94158; |

¹⁷

San Diego Zoo Institute for Conservation Research, Escondido, CA 92027; |

¹⁸

Department of Evolution, Behavior, and Ecology, Division of Biology, University of California San Diego, La Jolla, CA 92093; |

¹⁹

Department of Restorative Dentistry and Biomaterials Sciences, Harvard School of Dental Medicine, Boston, MA 02115; |

²⁰

School of Dental Medicine, Case Western Reserve University, Cleveland, OH 44106; |

²¹

Marine Mammal Program, Department of Vertebrate Zoology, Smithsonian Institution, Washington, DC 20002; |

²²

Science for Life Laboratory, Department of Medical Biochemistry and Microbiology, Uppsala University, 751 23 Uppsala, Sweden; |

²³

Bioinformatics and Integrative Biology, University of Massachusetts Medical School, Worcester, MA 01655; |

²⁴

Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01655; |

²⁵

Department of Evolution and Ecology, University of California, Davis, CA 95616; |

²⁶

John Muir Institute for the Environment, University of California, Davis, CA 95616 |

Publication type: Journal Article

Publication date: 2020-08-21

Proceedings of the National Academy of Sciences (PNAS)

Proceedings of the National Academy of Sciences of the United States of America

scimago Q1

wos Q1

SJR: 3.414

CiteScore: 16.5

Impact factor: 9.1

ISSN: 00278424, 10916490

DOI: 10.1073/pnas.2010146117

Copy DOI

PubMed ID: 32826334

Multidisciplinary

Abstract

Significance

The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of COVID-19, a major pandemic that threatens millions of human lives and the global economy. We identified a large number of mammals that can potentially be infected by SARS-CoV-2 via their ACE2 proteins. This can assist the identification of intermediate hosts for SARS-CoV-2 and hence reduce the opportunity for a future outbreak of COVID-19. Among the species we found with the highest risk for SARS-CoV-2 infection are wildlife and endangered species. These species represent an opportunity for spillover of SARS-CoV-2 from humans to other susceptible animals. Given the limited infectivity data for the species studied, we urge caution not to overinterpret the predictions of the present study.

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Chulalongkorn University

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GOST |

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GOST Copy

Damas J. et al. Broad host range of SARS-CoV-2 predicted by comparative and structural analysis of ACE2 in vertebrates // Proceedings of the National Academy of Sciences of the United States of America. 2020. Vol. 117. No. 36. pp. 22311-22322.

GOST all authors (up to 50) Copy

Damas J., Hughes G. M., Keough K. C., Painter C. A., Persky N. S., Corbo M., Hiller M. E., Koepfli K., Pfenning A., Zhao H., Genereux D. P., Swofford R., Pollard K., Ryder O. A., Nweeia M. T., Lindblad-Toh K., Teeling E. C., Karlsson E., LEWIN H. A. Broad host range of SARS-CoV-2 predicted by comparative and structural analysis of ACE2 in vertebrates // Proceedings of the National Academy of Sciences of the United States of America. 2020. Vol. 117. No. 36. pp. 22311-22322.

RIS |

Cite this

RIS Copy

TY - JOUR

DO - 10.1073/pnas.2010146117

UR - https://doi.org/10.1073/pnas.2010146117

TI - Broad host range of SARS-CoV-2 predicted by comparative and structural analysis of ACE2 in vertebrates

T2 - Proceedings of the National Academy of Sciences of the United States of America

AU - Damas, Joana

AU - Hughes, Graham M.

AU - Keough, Kathleen C

AU - Painter, Corrie A.

AU - Persky, Nicole S.

AU - Corbo, Marco

AU - Hiller, Michael Edward

AU - Koepfli, Klaus-Peter

AU - Pfenning, Andreas

AU - Zhao, Huabin

AU - Genereux, Diane P.

AU - Swofford, Ross

AU - Pollard, Katherine

AU - Ryder, Oliver A.

AU - Nweeia, Martin T

AU - Lindblad-Toh, Kerstin

AU - Teeling, Emma C.

AU - Karlsson, E.K.

AU - LEWIN, HARRIS A.

PY - 2020

DA - 2020/08/21

PB - Proceedings of the National Academy of Sciences (PNAS)

SP - 22311-22322

IS - 36

VL - 117

PMID - 32826334

SN - 0027-8424

SN - 1091-6490

ER -

BibTex |

Cite this

BibTex (up to 50 authors) Copy

@article{2020_Damas,

author = {Joana Damas and Graham M. Hughes and Kathleen C Keough and Corrie A. Painter and Nicole S. Persky and Marco Corbo and Michael Edward Hiller and Klaus-Peter Koepfli and Andreas Pfenning and Huabin Zhao and Diane P. Genereux and Ross Swofford and Katherine Pollard and Oliver A. Ryder and Martin T Nweeia and Kerstin Lindblad-Toh and Emma C. Teeling and E.K. Karlsson and HARRIS A. LEWIN},

title = {Broad host range of SARS-CoV-2 predicted by comparative and structural analysis of ACE2 in vertebrates},

journal = {Proceedings of the National Academy of Sciences of the United States of America},

year = {2020},

volume = {117},

publisher = {Proceedings of the National Academy of Sciences (PNAS)},

month = {aug},

url = {https://doi.org/10.1073/pnas.2010146117},

number = {36},

pages = {22311--22322},

doi = {10.1073/pnas.2010146117}

}

MLA

Cite this

MLA Copy

Damas, Joana, et al. “Broad host range of SARS-CoV-2 predicted by comparative and structural analysis of ACE2 in vertebrates.” Proceedings of the National Academy of Sciences of the United States of America, vol. 117, no. 36, Aug. 2020, pp. 22311-22322. https://doi.org/10.1073/pnas.2010146117.

Publisher

Proceedings of the National Academy of Sciences (PNAS)

Journal

Proceedings of the National Academy of Sciences of the United States of America

scimago Q1

wos Q1

SJR

3.414

CiteScore

16.5

Impact factor

9.1

ISSN

00278424 (Print)

10916490 (Electronic)