Open Access
,
volume 97
,
issue 20
,
pages 10978-10983
Rapid induction of senescence in human cervical carcinoma cells
Edward C Goodwin
1
,
Eva Yang
1
,
Chan-Jae Lee
1
,
Han-Woong LEE
1
,
Daniel Dimaio
1
,
Eun Seong Hwang
1
Publication type: Journal Article
Publication date: 2000-09-26
scimago Q1
wos Q1
SJR: 3.414
CiteScore: 16.5
Impact factor: 9.1
ISSN: 00278424, 10916490
PubMed ID:
11005870
Multidisciplinary
Abstract
Expression of the bovine papillomavirus E2 regulatory protein in human cervical carcinoma cell lines repressed expression of the resident human papillomavirus E6 and E7 oncogenes and within a few days caused essentially all of the cells to synchronously display numerous phenotypic markers characteristic of cells undergoing replicative senescence. This process was accompanied by marked but in some cases transient alterations in the expression of cell cycle regulatory proteins and by decreased telomerase activity. We propose that the human papillomavirus E6 and E7 proteins actively prevent senescence from occurring in cervical carcinoma cells, and that once viral oncogene expression is extinguished, the senescence program is rapidly executed. Activation of endogenous senescence pathways in cancer cells may represent an alternative approach to treat human cancers.
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173
Total citations:
173
Citations from 2024:
10
(5.78%)
Cite this
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Cite this
GOST
Copy
Goodwin E. C. et al. Rapid induction of senescence in human cervical carcinoma cells // Proceedings of the National Academy of Sciences of the United States of America. 2000. Vol. 97. No. 20. pp. 10978-10983.
GOST all authors (up to 50)
Copy
Goodwin E. C., Yang E., Lee C., LEE H., Dimaio D., Hwang E. S. Rapid induction of senescence in human cervical carcinoma cells // Proceedings of the National Academy of Sciences of the United States of America. 2000. Vol. 97. No. 20. pp. 10978-10983.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1073/pnas.97.20.10978
UR - https://doi.org/10.1073/pnas.97.20.10978
TI - Rapid induction of senescence in human cervical carcinoma cells
T2 - Proceedings of the National Academy of Sciences of the United States of America
AU - Goodwin, Edward C
AU - Yang, Eva
AU - Lee, Chan-Jae
AU - LEE, Han-Woong
AU - Dimaio, Daniel
AU - Hwang, Eun Seong
PY - 2000
DA - 2000/09/26
PB - Proceedings of the National Academy of Sciences (PNAS)
SP - 10978-10983
IS - 20
VL - 97
PMID - 11005870
SN - 0027-8424
SN - 1091-6490
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2000_Goodwin,
author = {Edward C Goodwin and Eva Yang and Chan-Jae Lee and Han-Woong LEE and Daniel Dimaio and Eun Seong Hwang},
title = {Rapid induction of senescence in human cervical carcinoma cells},
journal = {Proceedings of the National Academy of Sciences of the United States of America},
year = {2000},
volume = {97},
publisher = {Proceedings of the National Academy of Sciences (PNAS)},
month = {sep},
url = {https://doi.org/10.1073/pnas.97.20.10978},
number = {20},
pages = {10978--10983},
doi = {10.1073/pnas.97.20.10978}
}
Cite this
MLA
Copy
Goodwin, Edward C., et al. “Rapid induction of senescence in human cervical carcinoma cells.” Proceedings of the National Academy of Sciences of the United States of America, vol. 97, no. 20, Sep. 2000, pp. 10978-10983. https://doi.org/10.1073/pnas.97.20.10978.