Open Access
Proceedings of the National Academy of Sciences of the United States of America, volume 114, issue 26, pages 6675-6684
Prostaglandin E2 is essential for efficacious skeletal muscle stem-cell function, augmenting regeneration and strength
Andrew T V Ho
1
,
Adelaida R Palla
1
,
Matthew R Blake
1
,
Nora D Yucel
1
,
Yu-Xin Wang
1
,
Klas E G Magnusson
1, 2
,
Colin A Holbrook
1
,
Peggy E Kraft
1
,
SCOTT L. DELP
3
,
Helen M. Blau
1
Publication type: Journal Article
Publication date: 2017-06-12
Quartile SCImago
Q1
Quartile WOS
Q1
SJR: 3.737
CiteScore: 19.0
Impact factor: 9.4
ISSN: 00278424, 10916490
PubMed ID:
28607093
Multidisciplinary
Abstract
Significance
Muscle repair after injury entails an immune response that orchestrates efficacious regeneration. Here we identify Prostaglandin E2 (PGE2) as a crucial inflammatory mediator of muscle stem cells (MuSCs), the building blocks of muscle regeneration. PGE2 is synthesized and secreted into the stem-cell niche in response to injury, leading to robust MuSC proliferation, key to myofiber repair. EP4 is the receptor that mediates PGE2 signaling in MuSCs, and genetically engineered mice that lack EP4 in MuSCs have impaired regeneration. Nonsteroidal anti-inflammatory drugs (NSAIDs), commonly used to treat pain after muscle injury, inhibit PGE2 synthesis, hinder muscle regeneration, and lead to weakened muscles. Importantly, a single treatment of injured muscles with PGE2 dramatically accelerates muscle repair and recovery of strength.
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GOST
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Ho A. T. V. et al. Prostaglandin E2 is essential for efficacious skeletal muscle stem-cell function, augmenting regeneration and strength // Proceedings of the National Academy of Sciences of the United States of America. 2017. Vol. 114. No. 26. pp. 6675-6684.
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Ho A. T. V., Palla A. R., Blake M. R., Yucel N. D., Wang Y., Magnusson K. E. G., Holbrook C. A., Kraft P. E., DELP S. L., Blau H. M. Prostaglandin E2 is essential for efficacious skeletal muscle stem-cell function, augmenting regeneration and strength // Proceedings of the National Academy of Sciences of the United States of America. 2017. Vol. 114. No. 26. pp. 6675-6684.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1073/pnas.1705420114
UR - https://doi.org/10.1073/pnas.1705420114
TI - Prostaglandin E2 is essential for efficacious skeletal muscle stem-cell function, augmenting regeneration and strength
T2 - Proceedings of the National Academy of Sciences of the United States of America
AU - Ho, Andrew T V
AU - Palla, Adelaida R
AU - Blake, Matthew R
AU - Yucel, Nora D
AU - Wang, Yu-Xin
AU - Magnusson, Klas E G
AU - Holbrook, Colin A
AU - Kraft, Peggy E
AU - DELP, SCOTT L.
AU - Blau, Helen M.
PY - 2017
DA - 2017/06/12
PB - Proceedings of the National Academy of Sciences (PNAS)
SP - 6675-6684
IS - 26
VL - 114
PMID - 28607093
SN - 0027-8424
SN - 1091-6490
ER -
Cite this
BibTex
Copy
@article{2017_Ho,
author = {Andrew T V Ho and Adelaida R Palla and Matthew R Blake and Nora D Yucel and Yu-Xin Wang and Klas E G Magnusson and Colin A Holbrook and Peggy E Kraft and SCOTT L. DELP and Helen M. Blau},
title = {Prostaglandin E2 is essential for efficacious skeletal muscle stem-cell function, augmenting regeneration and strength},
journal = {Proceedings of the National Academy of Sciences of the United States of America},
year = {2017},
volume = {114},
publisher = {Proceedings of the National Academy of Sciences (PNAS)},
month = {jun},
url = {https://doi.org/10.1073/pnas.1705420114},
number = {26},
pages = {6675--6684},
doi = {10.1073/pnas.1705420114}
}
Cite this
MLA
Copy
Ho, Andrew T. V., et al. “Prostaglandin E2 is essential for efficacious skeletal muscle stem-cell function, augmenting regeneration and strength.” Proceedings of the National Academy of Sciences of the United States of America, vol. 114, no. 26, Jun. 2017, pp. 6675-6684. https://doi.org/10.1073/pnas.1705420114.