Open Access
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том 115
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издание 12
Peptides of pHLIP family for targeted intracellular and extracellular delivery of cargo molecules to tumors
Тип публикации: Journal Article
Дата публикации: 2018-03-05
scimago Q1
wos Q1
БС1
SJR: 3.414
CiteScore: 16.5
Impact factor: 9.1
ISSN: 00278424, 10916490
PubMed ID:
29507241
Multidisciplinary
Краткое описание
Significance
Targeted delivery has been limited by reliance on tumor cell biomarkers. The emergence of the pH (low) insertion peptide (pHLIP) technology provides an alternative by targeting a metabolic marker, tumor cell surface acidity. We report several new pHLIPs, including a new concept, pHLIP bundles, and we evaluate these constructs alongside a new generation of pHLIPs. We also discuss challenges inherent to the design and accurate evaluation of pHLIPs. Our research elucidates the strengths and weaknesses of existing pHLIPs, proposes future peptide modifications that could further improve tumor targeting, and discusses the applicability of this new generation of pHLIPs for specific areas of drug delivery. The principles and new constructs promise to advance applications to tumor therapy.
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Метрики
121
Всего цитирований:
121
Цитирований c 2025:
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(15.71%)
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ГОСТ
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Wyatt L. C. et al. Peptides of pHLIP family for targeted intracellular and extracellular delivery of cargo molecules to tumors // Proceedings of the National Academy of Sciences of the United States of America. 2018. Vol. 115. No. 12.
ГОСТ со всеми авторами (до 50)
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Wyatt L. C., Moshnikova A., Crawford T., Engelman D. M., Andreev O. A., Reshetnyak Y. K. Peptides of pHLIP family for targeted intracellular and extracellular delivery of cargo molecules to tumors // Proceedings of the National Academy of Sciences of the United States of America. 2018. Vol. 115. No. 12.
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RIS
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TY - JOUR
DO - 10.1073/pnas.1715350115
UR - https://doi.org/10.1073/pnas.1715350115
TI - Peptides of pHLIP family for targeted intracellular and extracellular delivery of cargo molecules to tumors
T2 - Proceedings of the National Academy of Sciences of the United States of America
AU - Wyatt, Linden C
AU - Moshnikova, Anna
AU - Crawford, Troy
AU - Engelman, Donald M
AU - Andreev, Oleg A.
AU - Reshetnyak, Yana K.
PY - 2018
DA - 2018/03/05
PB - Proceedings of the National Academy of Sciences (PNAS)
IS - 12
VL - 115
PMID - 29507241
SN - 0027-8424
SN - 1091-6490
ER -
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BibTex (до 50 авторов)
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@article{2018_Wyatt,
author = {Linden C Wyatt and Anna Moshnikova and Troy Crawford and Donald M Engelman and Oleg A. Andreev and Yana K. Reshetnyak},
title = {Peptides of pHLIP family for targeted intracellular and extracellular delivery of cargo molecules to tumors},
journal = {Proceedings of the National Academy of Sciences of the United States of America},
year = {2018},
volume = {115},
publisher = {Proceedings of the National Academy of Sciences (PNAS)},
month = {mar},
url = {https://doi.org/10.1073/pnas.1715350115},
number = {12},
doi = {10.1073/pnas.1715350115}
}