Open Access
,
том 115
,
издание 43
The structural basis for cancer drug interactions with the catalytic and allosteric sites of SAMHD1
Тип публикации: Journal Article
Дата публикации: 2018-10-10
scimago Q1
wos Q1
БС1
SJR: 3.414
CiteScore: 16.5
Impact factor: 9.1
ISSN: 00278424, 10916490
PubMed ID:
30305425
Multidisciplinary
Краткое описание
Significance
Nucleoside analog drugs are widely used to treat a variety of cancers and viral infections. With an essential role in regulating the nucleotide pool in the cell by degrading cellular nucleotides, SAMHD1 has the potential to decrease the cellular concentration of frequently prescribed nucleoside analogs and thereby decrease their clinical efficacy in cancer therapy. To improve future nucleoside analog treatments, it is important to understand SAMHD1 interactions with these drugs. Our work thoroughly examines the extent to which nucleotide analogs interact with the catalytic and allosteric sites of SAMHD1. This work contributes to the assessment of SAMHD1 as a potential therapeutic target for cancer therapy and the future design of SAMHD1 modulators that might improve the efficacy of existing therapies.
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ГОСТ
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Knecht K. M. et al. The structural basis for cancer drug interactions with the catalytic and allosteric sites of SAMHD1 // Proceedings of the National Academy of Sciences of the United States of America. 2018. Vol. 115. No. 43.
ГОСТ со всеми авторами (до 50)
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Knecht K. M., Buzovetsky O., Schneider C., Thomas D., Srikanth V., Kaderali L., Tofoleanu F., Reiss K., Ferreirós N., Geisslinger G., Batista V. S., Ji X., Cinatl J., Keppler O. T., Xiong Y. The structural basis for cancer drug interactions with the catalytic and allosteric sites of SAMHD1 // Proceedings of the National Academy of Sciences of the United States of America. 2018. Vol. 115. No. 43.
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TY - JOUR
DO - 10.1073/pnas.1805593115
UR - https://doi.org/10.1073/pnas.1805593115
TI - The structural basis for cancer drug interactions with the catalytic and allosteric sites of SAMHD1
T2 - Proceedings of the National Academy of Sciences of the United States of America
AU - Knecht, Kirsten M
AU - Buzovetsky, Olga
AU - Schneider, Constanze
AU - Thomas, Dominique
AU - Srikanth, Vishok
AU - Kaderali, Lars
AU - Tofoleanu, Florentina
AU - Reiss, Krystle
AU - Ferreirós, Nerea
AU - Geisslinger, Gerd
AU - Batista, Victor S.
AU - Ji, Xiaoyun
AU - Cinatl, Jindrich
AU - Keppler, Oliver T.
AU - Xiong, Yong
PY - 2018
DA - 2018/10/10
PB - Proceedings of the National Academy of Sciences (PNAS)
IS - 43
VL - 115
PMID - 30305425
SN - 0027-8424
SN - 1091-6490
ER -
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BibTex (до 50 авторов)
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@article{2018_Knecht,
author = {Kirsten M Knecht and Olga Buzovetsky and Constanze Schneider and Dominique Thomas and Vishok Srikanth and Lars Kaderali and Florentina Tofoleanu and Krystle Reiss and Nerea Ferreirós and Gerd Geisslinger and Victor S. Batista and Xiaoyun Ji and Jindrich Cinatl and Oliver T. Keppler and Yong Xiong},
title = {The structural basis for cancer drug interactions with the catalytic and allosteric sites of SAMHD1},
journal = {Proceedings of the National Academy of Sciences of the United States of America},
year = {2018},
volume = {115},
publisher = {Proceedings of the National Academy of Sciences (PNAS)},
month = {oct},
url = {https://doi.org/10.1073/pnas.1805593115},
number = {43},
doi = {10.1073/pnas.1805593115}
}