Open Access
Journal of Biological Chemistry, volume 284, issue 34, pages 22507-22511
Glycine N-Methyltransferase and Regulation of S-Adenosylmethionine Levels
1
From the ‡Department of Biochemistry, Vanderbilt University Medical Center, Nashville, Tennessee 37232
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2
the §Laboratory of Molecular Biology, National Institute of Mental Health, Bethesda, Maryland 20892
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Publication type: Journal Article
Publication date: 2009-08-01
Journal:
Journal of Biological Chemistry
Quartile SCImago
Q1
Quartile WOS
Q2
Impact factor: 4.8
ISSN: 00219258, 1083351X
PubMed ID:
19483083
Biochemistry
Molecular Biology
Cell Biology
Abstract
Methylation is a major biological process. It has been shown to be important in formation of compounds such as phosphatidylcholine, creatine, and many others and also participates in epigenetic effects through methylation of histones and DNA. The donor of methyl groups for almost all cellular methylation reactions is S-adenosylmethionine. It seems that the level of S-adenosylmethionine must be regulated in response to developmental stages and metabolic changes, and the enzyme glycine N-methyltransferase has been shown to play a major role in such regulation in mammals. This minireview will focus on the latest discoveries in the elucidation of the mechanism of that regulation.
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1 publication, 0.66%
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Citations by publishers
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Luka Z., Mudd S. H., Wagner C. Glycine N-Methyltransferase and Regulation of S-Adenosylmethionine Levels // Journal of Biological Chemistry. 2009. Vol. 284. No. 34. pp. 22507-22511.
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Luka Z., Mudd S. H., Wagner C. Glycine N-Methyltransferase and Regulation of S-Adenosylmethionine Levels // Journal of Biological Chemistry. 2009. Vol. 284. No. 34. pp. 22507-22511.
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TY - JOUR
DO - 10.1074/jbc.R109.019273
UR - https://doi.org/10.1074%2Fjbc.R109.019273
TI - Glycine N-Methyltransferase and Regulation of S-Adenosylmethionine Levels
T2 - Journal of Biological Chemistry
AU - Luka, Zigmund
AU - Mudd, S. Harvey
AU - Wagner, Conrad
PY - 2009
DA - 2009/08/01 00:00:00
PB - American Society for Biochemistry and Molecular Biology
SP - 22507-22511
IS - 34
VL - 284
PMID - 19483083
SN - 0021-9258
SN - 1083-351X
ER -
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BibTex
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@article{2009_Luka,
author = {Zigmund Luka and S. Harvey Mudd and Conrad Wagner},
title = {Glycine N-Methyltransferase and Regulation of S-Adenosylmethionine Levels},
journal = {Journal of Biological Chemistry},
year = {2009},
volume = {284},
publisher = {American Society for Biochemistry and Molecular Biology},
month = {aug},
url = {https://doi.org/10.1074%2Fjbc.R109.019273},
number = {34},
pages = {22507--22511},
doi = {10.1074/jbc.R109.019273}
}
Cite this
MLA
Copy
Luka, Zigmund, et al. “Glycine N-Methyltransferase and Regulation of S-Adenosylmethionine Levels.” Journal of Biological Chemistry, vol. 284, no. 34, Aug. 2009, pp. 22507-22511. https://doi.org/10.1074%2Fjbc.R109.019273.