Open Access
Molecular and Cellular Proteomics, volume 15, issue 9, pages 3030-3044
Defining the Protein-Protein Interaction Network of the Human Protein Tyrosine Phosphatase Family
1
From the ‡Department of Experimental Radiation Oncology, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030
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2
The University of Texas MD Anderson Cancer Center, United States
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3
Department of Developmental and Cell Biology, University of California, Irvine, California 92697.
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Publication type: Journal Article
Publication date: 2016-09-01
Journal:
Molecular and Cellular Proteomics
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 7
ISSN: 15359476, 15359484
PubMed ID:
27432908
Biochemistry
Molecular Biology
Analytical Chemistry
Abstract
Protein tyrosine phosphorylation, which plays a vital role in a variety of human cellular processes, is coordinated by protein tyrosine kinases and protein tyrosine phosphatases (PTPs). Genomic studies provide compelling evidence that PTPs are frequently mutated in various human cancers, suggesting that they have important roles in tumor suppression. However, the cellular functions and regulatory machineries of most PTPs are still largely unknown. To gain a comprehensive understanding of the protein-protein interaction network of the human PTP family, we performed a global proteomic study. Using a Minkowski distance-based unified scoring environment (MUSE) for the data analysis, we identified 940 high confidence candidate-interacting proteins that comprise the interaction landscape of the human PTP family. Through a gene ontology analysis and functional validations, we connected the PTP family with several key signaling pathways or cellular functions whose associations were previously unclear, such as the RAS-RAF-MEK pathway, the Hippo-YAP pathway, and cytokinesis. Our study provides the first glimpse of a protein interaction network for the human PTP family, linking it to a number of crucial signaling events, and generating a useful resource for future studies of PTPs.
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Li X. et al. Defining the Protein-Protein Interaction Network of the Human Protein Tyrosine Phosphatase Family // Molecular and Cellular Proteomics. 2016. Vol. 15. No. 9. pp. 3030-3044.
GOST all authors (up to 50)
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Li X., Tran K. M., Aziz K. E., Sorokin A. V., Junjie Chen J. C., Wang W. Defining the Protein-Protein Interaction Network of the Human Protein Tyrosine Phosphatase Family // Molecular and Cellular Proteomics. 2016. Vol. 15. No. 9. pp. 3030-3044.
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TY - JOUR
DO - 10.1074/mcp.M116.060277
UR - https://doi.org/10.1074%2Fmcp.M116.060277
TI - Defining the Protein-Protein Interaction Network of the Human Protein Tyrosine Phosphatase Family
T2 - Molecular and Cellular Proteomics
AU - Li, Xu
AU - Tran, Kim My
AU - Aziz, Kathryn E
AU - Sorokin, Alexey V
AU - Junjie Chen, Junjie Chen
AU - Wang, Wenqi
PY - 2016
DA - 2016/09/01 00:00:00
PB - American Society for Biochemistry and Molecular Biology
SP - 3030-3044
IS - 9
VL - 15
PMID - 27432908
SN - 1535-9476
SN - 1535-9484
ER -
Cite this
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@article{2016_Li,
author = {Xu Li and Kim My Tran and Kathryn E Aziz and Alexey V Sorokin and Junjie Chen Junjie Chen and Wenqi Wang},
title = {Defining the Protein-Protein Interaction Network of the Human Protein Tyrosine Phosphatase Family},
journal = {Molecular and Cellular Proteomics},
year = {2016},
volume = {15},
publisher = {American Society for Biochemistry and Molecular Biology},
month = {sep},
url = {https://doi.org/10.1074%2Fmcp.M116.060277},
number = {9},
pages = {3030--3044},
doi = {10.1074/mcp.M116.060277}
}
Cite this
MLA
Copy
Li, Xu, et al. “Defining the Protein-Protein Interaction Network of the Human Protein Tyrosine Phosphatase Family.” Molecular and Cellular Proteomics, vol. 15, no. 9, Sep. 2016, pp. 3030-3044. https://doi.org/10.1074%2Fmcp.M116.060277.