Microwave-Assisted Synthesis and Antifungal Activities of Polysubstituted Furo[3,2-c]chromen-4-ones and 7,8,9,10-Tetrahydro-6H-benzofuro[3,2-c]chromen-6-ones
Publication type: Journal Article
Publication date: 2014-09-04
scimago Q3
wos Q3
SJR: 0.322
CiteScore: 4.3
Impact factor: 1.8
ISSN: 00397911, 15322432
Organic Chemistry
Abstract
An efficient and novel microwave-assisted synthesis of furo[3,2-c]chromen-4-ones and 7,8,9,10-tetrahydro-6H-benzofuro[3,2-c]chromen-6-ones via 4-hydroxycoumarins with α-chloroketones or α-bromocyclohexanone in the presence of acetic acid (AcOH)/ammonium acetate (NH4OAc) using DMF as solvent under microwave irradiation is described. Systematically, antifungal biological tests showed that most of the compounds exhibited potent antifungal activity against Botrytis cinerea, Collecterichum capsica, Alternaria solani, Gibberella zeae, and Rhizoctorzia solani at the concentration of 50 µg/mL. The corresponding EC50 values of these analogues have been detected, and compound 4i showed better antifungal activity against tested fungi Botrytis cinerea and Collecterichum capsica than the reference Osthol.
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Zhang R. et al. Microwave-Assisted Synthesis and Antifungal Activities of Polysubstituted Furo[3,2-c]chromen-4-ones and 7,8,9,10-Tetrahydro-6H-benzofuro[3,2-c]chromen-6-ones // Synthetic Communications. 2014. Vol. 44. No. 22. pp. 3257-3263.
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Zhang R., Xu Z., Yin W., Liu P., Zhang W. Microwave-Assisted Synthesis and Antifungal Activities of Polysubstituted Furo[3,2-c]chromen-4-ones and 7,8,9,10-Tetrahydro-6H-benzofuro[3,2-c]chromen-6-ones // Synthetic Communications. 2014. Vol. 44. No. 22. pp. 3257-3263.
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TY - JOUR
DO - 10.1080/00397911.2014.935436
UR - https://doi.org/10.1080/00397911.2014.935436
TI - Microwave-Assisted Synthesis and Antifungal Activities of Polysubstituted Furo[3,2-c]chromen-4-ones and 7,8,9,10-Tetrahydro-6H-benzofuro[3,2-c]chromen-6-ones
T2 - Synthetic Communications
AU - Zhang, Rongrong
AU - Xu, Zichao
AU - Yin, Wenzheng
AU - Liu, Pin
AU - Zhang, Wei-Hua
PY - 2014
DA - 2014/09/04
PB - Taylor & Francis
SP - 3257-3263
IS - 22
VL - 44
SN - 0039-7911
SN - 1532-2432
ER -
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@article{2014_Zhang,
author = {Rongrong Zhang and Zichao Xu and Wenzheng Yin and Pin Liu and Wei-Hua Zhang},
title = {Microwave-Assisted Synthesis and Antifungal Activities of Polysubstituted Furo[3,2-c]chromen-4-ones and 7,8,9,10-Tetrahydro-6H-benzofuro[3,2-c]chromen-6-ones},
journal = {Synthetic Communications},
year = {2014},
volume = {44},
publisher = {Taylor & Francis},
month = {sep},
url = {https://doi.org/10.1080/00397911.2014.935436},
number = {22},
pages = {3257--3263},
doi = {10.1080/00397911.2014.935436}
}
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MLA
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Zhang, Rongrong, et al. “Microwave-Assisted Synthesis and Antifungal Activities of Polysubstituted Furo[3,2-c]chromen-4-ones and 7,8,9,10-Tetrahydro-6H-benzofuro[3,2-c]chromen-6-ones.” Synthetic Communications, vol. 44, no. 22, Sep. 2014, pp. 3257-3263. https://doi.org/10.1080/00397911.2014.935436.