Efficient Synthesis of (S)-3-(4-Fluorophenyl)morpholin-2-one, a Key Chiral Intermediate of Aprepitant
Publication type: Journal Article
Publication date: 2015-06-19
scimago Q3
wos Q3
SJR: 0.322
CiteScore: 4.3
Impact factor: 1.8
ISSN: 00397911, 15322432
Organic Chemistry
Abstract
AbstractA facile, economical, and practical method for the preparation of (S)-3-(4-fluorophenyl)morpholin-2-one [(S)-9] has been developed from ethyl 2-(4-fluorophenyl)-2-oxoacetate (7) in three steps through cyclization, hydrogenation, and resolution, providing a new and convenient access to the key intermediate of antiemetic drug aprepitant.
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Wang S. Efficient Synthesis of (S)-3-(4-Fluorophenyl)morpholin-2-one, a Key Chiral Intermediate of Aprepitant // Synthetic Communications. 2015. Vol. 45. No. 16. pp. 1871-1875.
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Wang S. Efficient Synthesis of (S)-3-(4-Fluorophenyl)morpholin-2-one, a Key Chiral Intermediate of Aprepitant // Synthetic Communications. 2015. Vol. 45. No. 16. pp. 1871-1875.
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TY - JOUR
DO - 10.1080/00397911.2015.1034872
UR - https://doi.org/10.1080/00397911.2015.1034872
TI - Efficient Synthesis of (S)-3-(4-Fluorophenyl)morpholin-2-one, a Key Chiral Intermediate of Aprepitant
T2 - Synthetic Communications
AU - Wang, Song-mei
PY - 2015
DA - 2015/06/19
PB - Taylor & Francis
SP - 1871-1875
IS - 16
VL - 45
SN - 0039-7911
SN - 1532-2432
ER -
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@article{2015_Wang,
author = {Song-mei Wang},
title = {Efficient Synthesis of (S)-3-(4-Fluorophenyl)morpholin-2-one, a Key Chiral Intermediate of Aprepitant},
journal = {Synthetic Communications},
year = {2015},
volume = {45},
publisher = {Taylor & Francis},
month = {jun},
url = {https://doi.org/10.1080/00397911.2015.1034872},
number = {16},
pages = {1871--1875},
doi = {10.1080/00397911.2015.1034872}
}
Cite this
MLA
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Wang, Song-mei. “Efficient Synthesis of (S)-3-(4-Fluorophenyl)morpholin-2-one, a Key Chiral Intermediate of Aprepitant.” Synthetic Communications, vol. 45, no. 16, Jun. 2015, pp. 1871-1875. https://doi.org/10.1080/00397911.2015.1034872.