Investigation of the effect of biologically active threo-Ds-isocitric acid on oxidative stress in Paramecium caudatum
Igor G Morgunov
1
,
I. G. Morgunov
1
,
Olga V Karpukhina
2
,
Svetlana V Kamzolova
1
,
S. V. Kamzolova
1
,
Vladimir A. Samoilenko
1
,
Anatoly N Inozemtsev
2
Publication type: Journal Article
Publication date: 2018-01-02
scimago Q3
wos Q3
SJR: 0.461
CiteScore: 5.0
Impact factor: 1.9
ISSN: 10826068, 15322297
PubMed ID:
28976247
Biochemistry
General Medicine
Biotechnology
Abstract
The effect of biologically active form (threo-Ds-) of isocitric acid (ICA) on oxidative stress was studied using the infusorian Paramecium caudatum stressed by hydrogen peroxide and salts of some heavy metals (Cu, Pb, Zn, and Cd). ICA at concentrations between 0.5 and 10 mM favorably influenced the infusorian cells with oxidative stress induced by the toxicants studied. The maximal antioxidant effect of ICA was observed at its concentration 10 mM irrespective of the toxicant used (either H2O2 or heavy metal ions). ICA was found to be a more active antioxidant than ascorbic acid. Biologically active pharmaceutically pure threo-Ds-ICA was produced through cultivation of the yeast Yarrowia lipolytica and isolated from the culture liquid in the form of crystalline monopotassium salt with a purity of 99.9%.
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GOST
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Morgunov I. G. et al. Investigation of the effect of biologically active threo-Ds-isocitric acid on oxidative stress in Paramecium caudatum // Preparative Biochemistry and Biotechnology. 2018. Vol. 48. No. 1. pp. 1-5.
GOST all authors (up to 50)
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Morgunov I. G., Morgunov I. G., Karpukhina O. V., Kamzolova S. V., Kamzolova S. V., Samoilenko V. A., Inozemtsev A. N. Investigation of the effect of biologically active threo-Ds-isocitric acid on oxidative stress in Paramecium caudatum // Preparative Biochemistry and Biotechnology. 2018. Vol. 48. No. 1. pp. 1-5.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1080/10826068.2017.1381622
UR - https://doi.org/10.1080/10826068.2017.1381622
TI - Investigation of the effect of biologically active threo-Ds-isocitric acid on oxidative stress in Paramecium caudatum
T2 - Preparative Biochemistry and Biotechnology
AU - Morgunov, Igor G
AU - Morgunov, I. G.
AU - Karpukhina, Olga V
AU - Kamzolova, Svetlana V
AU - Kamzolova, S. V.
AU - Samoilenko, Vladimir A.
AU - Inozemtsev, Anatoly N
PY - 2018
DA - 2018/01/02
PB - Taylor & Francis
SP - 1-5
IS - 1
VL - 48
PMID - 28976247
SN - 1082-6068
SN - 1532-2297
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2018_Morgunov,
author = {Igor G Morgunov and I. G. Morgunov and Olga V Karpukhina and Svetlana V Kamzolova and S. V. Kamzolova and Vladimir A. Samoilenko and Anatoly N Inozemtsev},
title = {Investigation of the effect of biologically active threo-Ds-isocitric acid on oxidative stress in Paramecium caudatum},
journal = {Preparative Biochemistry and Biotechnology},
year = {2018},
volume = {48},
publisher = {Taylor & Francis},
month = {jan},
url = {https://doi.org/10.1080/10826068.2017.1381622},
number = {1},
pages = {1--5},
doi = {10.1080/10826068.2017.1381622}
}
Cite this
MLA
Copy
Morgunov, Igor G., et al. “Investigation of the effect of biologically active threo-Ds-isocitric acid on oxidative stress in Paramecium caudatum.” Preparative Biochemistry and Biotechnology, vol. 48, no. 1, Jan. 2018, pp. 1-5. https://doi.org/10.1080/10826068.2017.1381622.