Total synthesis of (-)-2-methoxy-2-butenolide-3-cinnamate and its antimicrobial potentials
Madhukar S. Said
1, 2
,
Rohini Udavant
1
,
Amit Kumar Sahu
2, 3
,
Abujunaid Khan
2, 3
,
Rashmi Nayak
1, 2
,
Syed G. Dastager
2, 3
,
Pradeep Kumar
1, 2
,
Jayant Gajbhiye
1, 2
,
Jayant M. Gajbhiye
1, 2
2
Academy of Scientific and Innovative research (AcSIR), Ghaziabad, India
|
Publication type: Journal Article
Publication date: 2020-07-09
scimago Q2
wos Q3
SJR: 0.398
CiteScore: 5.2
Impact factor: 1.6
ISSN: 14786419, 14786427
PubMed ID:
32643424
Organic Chemistry
Biochemistry
Plant Science
Analytical Chemistry
Abstract
The first total synthesis of (-)-2-methoxy-2-butenolide-3-cinnamate (butenolide cinnamate) was achieved using commercially available starting material. The synthesized compound was found to have promising antibacterial activity against Gram-negative strains Escherichia coli (ATCC 8739), Salmonella typhimurium (ATCC 23564) and Pseudomonas aeruginosa (ATCC 19154) with a minimum inhibitory concentration of 2.0 µg/mL, 1.0 µg/mL and 2.0 µg/mL, respectively. Notably, the compound was more potent against Gram-negative test strains than the Gram-positive test strains.[Figure: see text].
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Said M. S. et al. Total synthesis of (-)-2-methoxy-2-butenolide-3-cinnamate and its antimicrobial potentials // Natural Product Research. 2020. Vol. 35. No. 23. pp. 5177-5182.
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Said M. S., Udavant R., Sahu A. K., Khan A., Nayak R., Dastager S. G., Kumar P., Gajbhiye J., M. Gajbhiye J. Total synthesis of (-)-2-methoxy-2-butenolide-3-cinnamate and its antimicrobial potentials // Natural Product Research. 2020. Vol. 35. No. 23. pp. 5177-5182.
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RIS
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TY - JOUR
DO - 10.1080/14786419.2020.1789979
UR - https://doi.org/10.1080/14786419.2020.1789979
TI - Total synthesis of (-)-2-methoxy-2-butenolide-3-cinnamate and its antimicrobial potentials
T2 - Natural Product Research
AU - Said, Madhukar S.
AU - Udavant, Rohini
AU - Sahu, Amit Kumar
AU - Khan, Abujunaid
AU - Nayak, Rashmi
AU - Dastager, Syed G.
AU - Kumar, Pradeep
AU - Gajbhiye, Jayant
AU - M. Gajbhiye, Jayant
PY - 2020
DA - 2020/07/09
PB - Taylor & Francis
SP - 5177-5182
IS - 23
VL - 35
PMID - 32643424
SN - 1478-6419
SN - 1478-6427
ER -
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BibTex (up to 50 authors)
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@article{2020_Said,
author = {Madhukar S. Said and Rohini Udavant and Amit Kumar Sahu and Abujunaid Khan and Rashmi Nayak and Syed G. Dastager and Pradeep Kumar and Jayant Gajbhiye and Jayant M. Gajbhiye},
title = {Total synthesis of (-)-2-methoxy-2-butenolide-3-cinnamate and its antimicrobial potentials},
journal = {Natural Product Research},
year = {2020},
volume = {35},
publisher = {Taylor & Francis},
month = {jul},
url = {https://doi.org/10.1080/14786419.2020.1789979},
number = {23},
pages = {5177--5182},
doi = {10.1080/14786419.2020.1789979}
}
Cite this
MLA
Copy
Said, Madhukar S., et al. “Total synthesis of (-)-2-methoxy-2-butenolide-3-cinnamate and its antimicrobial potentials.” Natural Product Research, vol. 35, no. 23, Jul. 2020, pp. 5177-5182. https://doi.org/10.1080/14786419.2020.1789979.