Syntheses and antitumor activities of D- and L-2'-deoxy-4'-thio pyrimidine nucleosides
Тип публикации: Journal Article
Дата публикации: 1994-07-01
Biochemistry
Genetics
Краткое описание
Abstract Both enantiomers of 2′-deoxy-4′-thiouridine (9) and 15, 4′-thiothymidine (10) and 16, and 2′-deoxy-4′-thiocytidine (14) and 17 and 1-(2-deoxy-4-thio-β-D-erythro-pentafuranosyl)-5-trifluoromethyluracil (11) were synthesized. The key coupling reactions were performed by the reaction of D- or L-enantiomers of ethyl 5-O-acetyl-3-O-(tert-butyldimethylsilyl)-2-deoxy-4-thio-α, β3-xylofuranoside (1)) or 18 and 2,4-bis(trimethylsilyloxy)pyrimidine in the presence of SnCl4 in acetonitrile. Cytotoxicities against L-1210 and KB-cells for the compounds 9, 10, 11, 14, 15, 16, and 17 were examined. The compounds 10 and 11 were potentially active.
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Uenishi J. et al. Syntheses and antitumor activities of D- and L-2'-deoxy-4'-thio pyrimidine nucleosides // Nucleosides and Nucleotides. 1994. Vol. 13. No. 6-7. pp. 1347-1361.
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Uenishi J., Takahashi K., MOTOYAMA M., Akashi H., Sasaki T. Syntheses and antitumor activities of D- and L-2'-deoxy-4'-thio pyrimidine nucleosides // Nucleosides and Nucleotides. 1994. Vol. 13. No. 6-7. pp. 1347-1361.
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TY - JOUR
DO - 10.1080/15257779408012157
UR - https://doi.org/10.1080/15257779408012157
TI - Syntheses and antitumor activities of D- and L-2'-deoxy-4'-thio pyrimidine nucleosides
T2 - Nucleosides and Nucleotides
AU - Uenishi, Junichi
AU - Takahashi, Keiji
AU - MOTOYAMA, MITSUHIRO
AU - Akashi, Haruo
AU - Sasaki, Takuma
PY - 1994
DA - 1994/07/01
PB - Taylor & Francis
SP - 1347-1361
IS - 6-7
VL - 13
SN - 0732-8311
ER -
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@article{1994_Uenishi,
author = {Junichi Uenishi and Keiji Takahashi and MITSUHIRO MOTOYAMA and Haruo Akashi and Takuma Sasaki},
title = {Syntheses and antitumor activities of D- and L-2'-deoxy-4'-thio pyrimidine nucleosides},
journal = {Nucleosides and Nucleotides},
year = {1994},
volume = {13},
publisher = {Taylor & Francis},
month = {jul},
url = {https://doi.org/10.1080/15257779408012157},
number = {6-7},
pages = {1347--1361},
doi = {10.1080/15257779408012157}
}
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MLA
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Uenishi, Junichi, et al. “Syntheses and antitumor activities of D- and L-2'-deoxy-4'-thio pyrimidine nucleosides.” Nucleosides and Nucleotides, vol. 13, no. 6-7, Jul. 1994, pp. 1347-1361. https://doi.org/10.1080/15257779408012157.