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том 31
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издание 1
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страницы 1-6
Isolation and identification of novel propoxyphenyl thiosildenafil found in natural health food product
Kyoung Moon Han
1
,
Ji Hyun Lee
2
,
Hyoung Joon Park
2
,
Insun Hwang
2
,
Ok Soon Heo
2
,
Woo-Seong Kim
2
1
a Advanced Analysis Team, Toxicological Evaluation and Research Department , National Institute of Food and Drug Safety Evaluation , Ministry of Food and Drug Safety , Cheongwon-gun , Korea.
|
2
Advanced Analysis Team, Toxicological Evaluation and Research Department, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety, Cheongwon-gun, Korea
|
Тип публикации: Journal Article
Дата публикации: 2014-01-02
scimago Q2
wos Q3
БС1
SJR: 0.526
CiteScore: 8.2
Impact factor: 2.2
ISSN: 19440049, 19440057
PubMed ID:
24382302
General Chemistry
General Medicine
Food Science
Health, Toxicology and Mutagenesis
Public Health, Environmental and Occupational Health
Toxicology
Краткое описание
A novel phosphodiesterase-5 (PDE-5) inhibitor was found in a natural health food product. The previously unknown sildenafil analogue was isolated using preparative HPLC. The structure of the compound was elucidated using HPLC with diode array detection (DAD), time-of-flight mass spectrometry (TOF/MS), and nuclear magnetic resonance spectroscopy (NMR). An [M + H](+) ion was detected at m/z 505.2077 by LC-TOF/MS that was consistent with C23H32N6O3S2 (-0.98 ppm). By NMR analysis, the analogue was identified as 1-methyl-5-(5-(4-methylpiperazin-1-ylsulfonyl)-2-propoxyphenyl)-3-propyl-1H-pyrazolo[4,3-d]pyrimidine-7(6H)-thione. In this structure, the ethoxy group of thiosildenafil was substituted by a propoxy group of the unknown compound. Therefore, this novel thiosildenafil analogue was named propoxyphenyl thiosildenafil.
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ГОСТ
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Han K. M. et al. Isolation and identification of novel propoxyphenyl thiosildenafil found in natural health food product // Food Additives and Contaminants - Part A Chemistry, Analysis, Control, Exposure and Risk Assessment. 2014. Vol. 31. No. 1. pp. 1-6.
ГОСТ со всеми авторами (до 50)
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Han K. M., Lee J. H., Park H. J., Hwang I., Heo O. S., Kim W. Isolation and identification of novel propoxyphenyl thiosildenafil found in natural health food product // Food Additives and Contaminants - Part A Chemistry, Analysis, Control, Exposure and Risk Assessment. 2014. Vol. 31. No. 1. pp. 1-6.
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RIS
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TY - JOUR
DO - 10.1080/19440049.2013.855948
UR - https://doi.org/10.1080/19440049.2013.855948
TI - Isolation and identification of novel propoxyphenyl thiosildenafil found in natural health food product
T2 - Food Additives and Contaminants - Part A Chemistry, Analysis, Control, Exposure and Risk Assessment
AU - Han, Kyoung Moon
AU - Lee, Ji Hyun
AU - Park, Hyoung Joon
AU - Hwang, Insun
AU - Heo, Ok Soon
AU - Kim, Woo-Seong
PY - 2014
DA - 2014/01/02
PB - Taylor & Francis
SP - 1-6
IS - 1
VL - 31
PMID - 24382302
SN - 1944-0049
SN - 1944-0057
ER -
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BibTex (до 50 авторов)
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@article{2014_Han,
author = {Kyoung Moon Han and Ji Hyun Lee and Hyoung Joon Park and Insun Hwang and Ok Soon Heo and Woo-Seong Kim},
title = {Isolation and identification of novel propoxyphenyl thiosildenafil found in natural health food product},
journal = {Food Additives and Contaminants - Part A Chemistry, Analysis, Control, Exposure and Risk Assessment},
year = {2014},
volume = {31},
publisher = {Taylor & Francis},
month = {jan},
url = {https://doi.org/10.1080/19440049.2013.855948},
number = {1},
pages = {1--6},
doi = {10.1080/19440049.2013.855948}
}
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MLA
Скопировать
Han, Kyoung Moon, et al. “Isolation and identification of novel propoxyphenyl thiosildenafil found in natural health food product.” Food Additives and Contaminants - Part A Chemistry, Analysis, Control, Exposure and Risk Assessment, vol. 31, no. 1, Jan. 2014, pp. 1-6. https://doi.org/10.1080/19440049.2013.855948.