Identification of a new tadalafil analogue in commercial dietary supplements: isopropylnortadalafil

Han Na Park 1
, 
Ji Hyun Lee 1
, 
Sung-Kwan Park 1
, 
Jongkook Lee 2
, 
Hwan Seong Choi 1
1
 
a Advanced Analysis Team, Toxicological Evaluation and Research Department , National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety , Cheongju-si , Chungcheongbuk-do , South Korea. | 
2
 
Publication type: Journal Article
Publication date: 2016-12-22
Taylor & Francis
scimago Q2
wos Q3
SJR: 0.526
CiteScore: 8.2
Impact factor: 2.2
ISSN: 19440049, 19440057
General Chemistry
General Medicine
Food Science
Health, Toxicology and Mutagenesis
Public Health, Environmental and Occupational Health
Toxicology
Abstract
A new tadalafil analogue was found in a commercial dietary supplement for enhancing sexual performance. The compound was detected by a high-performance liquid chromatography-diode array detector (HPLC-DAD). The analogue was isolated using semi-preparative HPLC, and its accurate mass was established by two LC-high-resolution-mass spectrometers (LC-HRMS). The structure was determined by nuclear magnetic resonance (NMR) spectroscopy. The accurate mass of the compound corresponded to a molecular formula of C24H23N3O4. The compound was identified as a structural analogue of tadalafil in which the N-methyl group of tadalafil was replaced with an N-isopropyl group. We have named the new analogue isopropylnortadalafil and it is first reported herein.
Found 
Found 

Top-30

Publishers

1
Elsevier
Elsevier, 1, 50%
Elsevier
1 publication, 50%
Taylor & Francis
Taylor & Francis, 1, 50%
Taylor & Francis
1 publication, 50%
1
  • We do not take into account publications without a DOI.
  • Statistics recalculated weekly.

Are you a researcher?

Create a profile to get free access to personal recommendations for colleagues and new articles.
Metrics
2
Share
Cite this
GOST |
Cite this
GOST Copy
Park H. N. et al. Identification of a new tadalafil analogue in commercial dietary supplements: isopropylnortadalafil // Food Additives and Contaminants - Part A Chemistry, Analysis, Control, Exposure and Risk Assessment. 2016. Vol. 34. No. 2. pp. 1-8.
GOST all authors (up to 50) Copy
Park H. N., Lee J. H., Park S., Lee J., Choi H. S. Identification of a new tadalafil analogue in commercial dietary supplements: isopropylnortadalafil // Food Additives and Contaminants - Part A Chemistry, Analysis, Control, Exposure and Risk Assessment. 2016. Vol. 34. No. 2. pp. 1-8.
RIS |
Cite this
RIS Copy
TY - JOUR
DO - 10.1080/19440049.2016.1263878
UR - https://doi.org/10.1080/19440049.2016.1263878
TI - Identification of a new tadalafil analogue in commercial dietary supplements: isopropylnortadalafil
T2 - Food Additives and Contaminants - Part A Chemistry, Analysis, Control, Exposure and Risk Assessment
AU - Park, Han Na
AU - Lee, Ji Hyun
AU - Park, Sung-Kwan
AU - Lee, Jongkook
AU - Choi, Hwan Seong
PY - 2016
DA - 2016/12/22
PB - Taylor & Francis
SP - 1-8
IS - 2
VL - 34
PMID - 28004593
SN - 1944-0049
SN - 1944-0057
ER -
BibTex |
Cite this
BibTex (up to 50 authors) Copy
@article{2016_Park,
author = {Han Na Park and Ji Hyun Lee and Sung-Kwan Park and Jongkook Lee and Hwan Seong Choi},
title = {Identification of a new tadalafil analogue in commercial dietary supplements: isopropylnortadalafil},
journal = {Food Additives and Contaminants - Part A Chemistry, Analysis, Control, Exposure and Risk Assessment},
year = {2016},
volume = {34},
publisher = {Taylor & Francis},
month = {dec},
url = {https://doi.org/10.1080/19440049.2016.1263878},
number = {2},
pages = {1--8},
doi = {10.1080/19440049.2016.1263878}
}
MLA
Cite this
MLA Copy
Park, Han Na, et al. “Identification of a new tadalafil analogue in commercial dietary supplements: isopropylnortadalafil.” Food Additives and Contaminants - Part A Chemistry, Analysis, Control, Exposure and Risk Assessment, vol. 34, no. 2, Dec. 2016, pp. 1-8. https://doi.org/10.1080/19440049.2016.1263878.