Open Access
m6A demethylase FTO regulates the apoptosis and inflammation of cardiomyocytes via YAP1 in ischemia-reperfusion injury
Publication type: Journal Article
Publication date: 2022-02-17
scimago Q1
SJR: 1.051
CiteScore: 12.4
Impact factor: —
ISSN: 21655979, 21655987
PubMed ID:
35176940
General Medicine
Applied Microbiology and Biotechnology
Biotechnology
Bioengineering
Abstract
Reperfusion therapy after acute myocardial infarction can induce myocardial ischemia-reperfusion injury (IRI). Novel evidence has illustrated that N6-methyladenosine (m6A) modification modulates the myocardial IRI progression. Here, our study focuses on the role of m6A methyltransferase fat mass and obesity-associated protein (FTO) in myocardial ischemia/reoxygenation injury and explores potential regulatory mechanisms. Results discovered that FTO down-expressed in myocardial IRI mice and hypoxia/reoxygenation (H/R)-induced cardiomyocytes. Functionally, FTO overexpression attenuated the H/R-induced apoptosis and inflammation of cardiomyocytes. Mechanistically, methylated RNA immunoprecipitation quantitative polymerase chain reaction (MeRIP-qPCR) assay and RIP assay revealed that Yap1 mRNA acted as the target of FTO in cardiomyocytes. Moreover, FTO uninstalled the methylation of Yap1 mRNA, and enforced the stability of Yap1 mRNA. Taken together, our study reveals the role of FTO in H/R-induced myocardial cell injury via m6A-dependent manner, which may provide a new approach to improve myocardial IRI.
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Metrics
58
Total citations:
58
Citations from 2024:
34
(58.62%)
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GOST
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Ke W. et al. m6A demethylase FTO regulates the apoptosis and inflammation of cardiomyocytes via YAP1 in ischemia-reperfusion injury // Bioengineered. 2022. Vol. 13. No. 3. pp. 5443-5452.
GOST all authors (up to 50)
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Ke W., Huang Z., Peng C. L., Ke Y. P. m6A demethylase FTO regulates the apoptosis and inflammation of cardiomyocytes via YAP1 in ischemia-reperfusion injury // Bioengineered. 2022. Vol. 13. No. 3. pp. 5443-5452.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1080/21655979.2022.2030572
UR - https://doi.org/10.1080/21655979.2022.2030572
TI - m6A demethylase FTO regulates the apoptosis and inflammation of cardiomyocytes via YAP1 in ischemia-reperfusion injury
T2 - Bioengineered
AU - Ke, Wei-Liang
AU - Huang, Zhi-wen
AU - Peng, Chun Ling
AU - Ke, Yi Ping
PY - 2022
DA - 2022/02/17
PB - Taylor & Francis
SP - 5443-5452
IS - 3
VL - 13
PMID - 35176940
SN - 2165-5979
SN - 2165-5987
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2022_Ke,
author = {Wei-Liang Ke and Zhi-wen Huang and Chun Ling Peng and Yi Ping Ke},
title = {m6A demethylase FTO regulates the apoptosis and inflammation of cardiomyocytes via YAP1 in ischemia-reperfusion injury},
journal = {Bioengineered},
year = {2022},
volume = {13},
publisher = {Taylor & Francis},
month = {feb},
url = {https://doi.org/10.1080/21655979.2022.2030572},
number = {3},
pages = {5443--5452},
doi = {10.1080/21655979.2022.2030572}
}
Cite this
MLA
Copy
Ke, Wei-Liang, et al. “m6A demethylase FTO regulates the apoptosis and inflammation of cardiomyocytes via YAP1 in ischemia-reperfusion injury.” Bioengineered, vol. 13, no. 3, Feb. 2022, pp. 5443-5452. https://doi.org/10.1080/21655979.2022.2030572.