Analytical Letters, volume 47, issue 8, pages 1275-1289
Determination of Tyrosine and Its Metabolites in Human Serum with Application to Cancer Diagnosis
Publication type: Journal Article
Publication date: 2014-05-02
Journal:
Analytical Letters
Quartile SCImago
Q3
Quartile WOS
Q3
Impact factor: 2
ISSN: 00032719, 1532236X
Biochemistry
Spectroscopy
Clinical Biochemistry
Analytical Chemistry
Electrochemistry
Biochemistry (medical)
Abstract
A simple, rapid, and economical method is reported for the determination of 3,4-dihydroxyphenylalanine, tyrosine, 4-hydroxyphenyllactic acid, 4-hydroxyphenylacetic acid, 4-hydroxyphenethylamine, and 3-(4-hydroxyphenyl)propionic acid in human serum by ultra-performance liquid chromatography coupled with fluorescence detection. Separation was achieved on a C18 column with isocratic elution using 95:5 (v/v) 50 mM ammonium formate buffer at pH 5.8 and acetonitrile. Fluorescence detection was performed with excitation and emission wavelengths of 277 and 316 nm, respectively. Under the optimized conditions, all compounds were eluted within 10 min. The effectiveness of various protein precipitants was investigated for the pretreatment of serum samples and 5% perchloric acid was selected as optimal. The calibration curves were linear (correlation coefficients > 0.9996), and the limits of detection and quantification for tyrosine and its metabolites ranged from 0.016 to 0.032 mg/L and 0.040 to 0.080 mg/L, respecti...
Top-30
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- Statistics recalculated weekly.
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Feng L. et al. Determination of Tyrosine and Its Metabolites in Human Serum with Application to Cancer Diagnosis // Analytical Letters. 2014. Vol. 47. No. 8. pp. 1275-1289.
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Feng L., He Y., Xu G., Hu H., Guo L., Wan Y. Determination of Tyrosine and Its Metabolites in Human Serum with Application to Cancer Diagnosis // Analytical Letters. 2014. Vol. 47. No. 8. pp. 1275-1289.
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TY - JOUR
DO - 10.1080/00032719.2013.871549
UR - https://doi.org/10.1080/00032719.2013.871549
TI - Determination of Tyrosine and Its Metabolites in Human Serum with Application to Cancer Diagnosis
T2 - Analytical Letters
AU - Feng, Lei
AU - He, Yuan-qiao
AU - Xu, Guo-Hui
AU - Hu, Hui
AU - Guo, Lan
AU - Wan, Yiqun
PY - 2014
DA - 2014/05/02 00:00:00
PB - Taylor & Francis
SP - 1275-1289
IS - 8
VL - 47
SN - 0003-2719
SN - 1532-236X
ER -
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@article{2014_Feng,
author = {Lei Feng and Yuan-qiao He and Guo-Hui Xu and Hui Hu and Lan Guo and Yiqun Wan},
title = {Determination of Tyrosine and Its Metabolites in Human Serum with Application to Cancer Diagnosis},
journal = {Analytical Letters},
year = {2014},
volume = {47},
publisher = {Taylor & Francis},
month = {may},
url = {https://doi.org/10.1080/00032719.2013.871549},
number = {8},
pages = {1275--1289},
doi = {10.1080/00032719.2013.871549}
}
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MLA
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Feng, Lei, et al. “Determination of Tyrosine and Its Metabolites in Human Serum with Application to Cancer Diagnosis.” Analytical Letters, vol. 47, no. 8, May. 2014, pp. 1275-1289. https://doi.org/10.1080/00032719.2013.871549.