An Improved Method for the Preparation OF 3,5-Difluorosalicylaldehyde and 3,5-Difluorosalicylic Acid#
1
Drug Discovery, The R.W. Johnson Pharmaceutical Research Institute , 1000 Route 202, Raritan, N.J., 08869
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Publication type: Journal Article
Publication date: 1996-07-01
scimago Q3
wos Q3
SJR: 0.322
CiteScore: 4.3
Impact factor: 1.8
ISSN: 00397911, 15322432
Organic Chemistry
Abstract
An improved method for the synthesis of 3,5-difluorosalicylic acid (3b) and 3,5-difluorosalicylaldehyde (3a) is described. 2,4-Difluorophenol (4) undergoes a formylation reaction to afford aldehyde 3a which is oxidized to the desired acid 3b. This method avoids the use of the highly corrosive HF and fluorine gas and requires no special laboratory apparatus. #Dedicated to the memory of Rosemarie R. Ungarelli, Academic Advisor, Chemistry Department, Long Island Univeristy, C.W. Post Center.
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Total citations:
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Citations from 2024:
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(11.11%)
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Weidner-Wells M. A., Fraga-Spano S. A. An Improved Method for the Preparation OF 3,5-Difluorosalicylaldehyde and 3,5-Difluorosalicylic Acid# // Synthetic Communications. 1996. Vol. 26. No. 14. pp. 2775-2781.
GOST all authors (up to 50)
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Weidner-Wells M. A., Fraga-Spano S. A. An Improved Method for the Preparation OF 3,5-Difluorosalicylaldehyde and 3,5-Difluorosalicylic Acid# // Synthetic Communications. 1996. Vol. 26. No. 14. pp. 2775-2781.
Cite this
RIS
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TY - JOUR
DO - 10.1080/00397919608004595
UR - https://doi.org/10.1080/00397919608004595
TI - An Improved Method for the Preparation OF 3,5-Difluorosalicylaldehyde and 3,5-Difluorosalicylic Acid#
T2 - Synthetic Communications
AU - Weidner-Wells, Michele A
AU - Fraga-Spano, Stephanie A
PY - 1996
DA - 1996/07/01
PB - Taylor & Francis
SP - 2775-2781
IS - 14
VL - 26
SN - 0039-7911
SN - 1532-2432
ER -
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BibTex (up to 50 authors)
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@article{1996_Weidner-Wells,
author = {Michele A Weidner-Wells and Stephanie A Fraga-Spano},
title = {An Improved Method for the Preparation OF 3,5-Difluorosalicylaldehyde and 3,5-Difluorosalicylic Acid#},
journal = {Synthetic Communications},
year = {1996},
volume = {26},
publisher = {Taylor & Francis},
month = {jul},
url = {https://doi.org/10.1080/00397919608004595},
number = {14},
pages = {2775--2781},
doi = {10.1080/00397919608004595}
}
Cite this
MLA
Copy
Weidner-Wells, Michele A., and Stephanie A Fraga-Spano. “An Improved Method for the Preparation OF 3,5-Difluorosalicylaldehyde and 3,5-Difluorosalicylic Acid#.” Synthetic Communications, vol. 26, no. 14, Jul. 1996, pp. 2775-2781. https://doi.org/10.1080/00397919608004595.