Amino-Substituted GEM-Bisphosphonates
Тип публикации: Journal Article
Дата публикации: 1999-01-01
SCImago Q4
WOS Q3
БС3
SJR: 0.213
CiteScore: 2.7
Impact factor: 1.3
ISSN: 10426507, 15635325, 10267719
Organic Chemistry
Biochemistry
Inorganic Chemistry
Краткое описание
In 1986, a chemistry program was initiated to discover a more potent bisphosphonate as a follow-up to pamidronate for the treatment of osteoporosis and metastatic bone disease. Three subclasses of bisphosphonates were investigated: 1) analogues of pamidronate with different alkyl and phenyl-X-alkyl-substituents (X = O, S) at the nitrogen (tables 1 and 2); 2) hydroxy bisphosphonates with a five-membered heteroaromatic substitutent linked via a methylene bridge to C1 (table III); 3) aminomethylene bisphosphonates with a five-membered heteroaromatic substitutent (table IV). Zoledronate was selected for development based on its high antiresorptive activity, good dissociation from inhibition of bone mineralization and excellent renal tolerability. Preliminary results from Phase I clinical trials have confirmed the compound's predicted profile.
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ГОСТ
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Widler L. et al. Amino-Substituted GEM-Bisphosphonates // Phosphorus, Sulfur and Silicon and the Related Elements. 1999. Vol. 144. No. 1. pp. 5-8.
ГОСТ со всеми авторами (до 50)
Скопировать
Widler L., Jaeggi K. A., Green J. R. Amino-Substituted GEM-Bisphosphonates // Phosphorus, Sulfur and Silicon and the Related Elements. 1999. Vol. 144. No. 1. pp. 5-8.
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RIS
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TY - JOUR
DO - 10.1080/10426509908546168
UR - https://doi.org/10.1080/10426509908546168
TI - Amino-Substituted GEM-Bisphosphonates
T2 - Phosphorus, Sulfur and Silicon and the Related Elements
AU - Widler, Leo
AU - Jaeggi, Knut A
AU - Green, Jonathan R.
PY - 1999
DA - 1999/01/01
PB - Taylor & Francis
SP - 5-8
IS - 1
VL - 144
SN - 1042-6507
SN - 1563-5325
SN - 1026-7719
ER -
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BibTex (до 50 авторов)
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@article{1999_Widler,
author = {Leo Widler and Knut A Jaeggi and Jonathan R. Green},
title = {Amino-Substituted GEM-Bisphosphonates},
journal = {Phosphorus, Sulfur and Silicon and the Related Elements},
year = {1999},
volume = {144},
publisher = {Taylor & Francis},
month = {jan},
url = {https://doi.org/10.1080/10426509908546168},
number = {1},
pages = {5--8},
doi = {10.1080/10426509908546168}
}
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MLA
Скопировать
Widler, Leo, et al. “Amino-Substituted GEM-Bisphosphonates.” Phosphorus, Sulfur and Silicon and the Related Elements, vol. 144, no. 1, Jan. 1999, pp. 5-8. https://doi.org/10.1080/10426509908546168.
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