Open Access
Cleavable PEGylation: a strategy for overcoming the “PEG dilemma” in efficient drug delivery
Тип публикации: Journal Article
Дата публикации: 2017-10-25
scimago Q1
wos Q1
БС1
SJR: 1.380
CiteScore: 16.4
Impact factor: 8.1
ISSN: 10717544, 15210464
PubMed ID:
29069920
General Medicine
Pharmaceutical Science
Краткое описание
Abstract To prolong the circulation time of drug, PEGylation has been widely used via the enhanced permeability and retention (EPR) effect, thereby providing new hope for better treatment. However, PEGylation also brings the "PEG dilemma", which is difficult for the cellular absorption of drugs and subsequent endosomal escape. As a result, the activity of drugs is inevitably lost after PEG modification. To achieve successful drug delivery for effective treatment, the crucial issue associated with the use of PEG-lipids, that is, “PEG dilemma” must be addressed. In this paper, we introduced the development and application of nanocarriers with cleavable PEGylation, and discussed various strategies for overcoming the PEG dilemma. Compared to the traditional ones, the vehicle systems with different environmental-sensitive PEG-lipids were discussed, which cleavage can be achieved in response to the intracellular as well as the tumor microenvironment. This smart cleavable PEGylation provides us an efficient strategy to overcome “PEG dilemma”, thereby may be a good candidate for the cancer treatment in future.
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Метрики
318
Всего цитирований:
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Цитирований c 2024:
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(34.6%)
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ГОСТ
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Fang Y. et al. Cleavable PEGylation: a strategy for overcoming the “PEG dilemma” in efficient drug delivery // Drug Delivery. 2017. Vol. 24. No. 2. pp. 22-32.
ГОСТ со всеми авторами (до 50)
Скопировать
Fang Y., Xue J., Gao S., Lu A., Yang D., Jiang H., Yang H., SHI K. Cleavable PEGylation: a strategy for overcoming the “PEG dilemma” in efficient drug delivery // Drug Delivery. 2017. Vol. 24. No. 2. pp. 22-32.
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TY - JOUR
DO - 10.1080/10717544.2017.1388451
UR - https://doi.org/10.1080/10717544.2017.1388451
TI - Cleavable PEGylation: a strategy for overcoming the “PEG dilemma” in efficient drug delivery
T2 - Drug Delivery
AU - Fang, Yan
AU - Xue, Jianxiu
AU - Gao, Shan
AU - Lu, Anqi
AU - Yang, Dongjuan
AU - Jiang, Hong
AU - Yang, He
AU - SHI, KAI
PY - 2017
DA - 2017/10/25
PB - Taylor & Francis
SP - 22-32
IS - 2
VL - 24
PMID - 29069920
SN - 1071-7544
SN - 1521-0464
ER -
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BibTex (до 50 авторов)
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@article{2017_Fang,
author = {Yan Fang and Jianxiu Xue and Shan Gao and Anqi Lu and Dongjuan Yang and Hong Jiang and He Yang and KAI SHI},
title = {Cleavable PEGylation: a strategy for overcoming the “PEG dilemma” in efficient drug delivery},
journal = {Drug Delivery},
year = {2017},
volume = {24},
publisher = {Taylor & Francis},
month = {oct},
url = {https://doi.org/10.1080/10717544.2017.1388451},
number = {2},
pages = {22--32},
doi = {10.1080/10717544.2017.1388451}
}
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MLA
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Fang, Yan, et al. “Cleavable PEGylation: a strategy for overcoming the “PEG dilemma” in efficient drug delivery.” Drug Delivery, vol. 24, no. 2, Oct. 2017, pp. 22-32. https://doi.org/10.1080/10717544.2017.1388451.