THE INFLUENCE OF MOBILE-PHASE FLOW-RATE IN RP-LC ON THERMODYNAMIC PARAMETERS STUDIED FOR POLAR COMPOUNDS
1
a Bioanalytical Laboratory, S.C. LaborMed Pharma S.A. , Bucharest, Romania
|
Publication type: Journal Article
Publication date: 2011-03-26
scimago Q3
wos Q4
SJR: 0.240
CiteScore: 2.2
Impact factor: 1.2
ISSN: 10826076, 1520572X
Biochemistry
Pharmaceutical Science
Clinical Biochemistry
Analytical Chemistry
Abstract
Thermodynamic parameters, such as standard enthalpy (ΔH0) and entropic contributions (ΔS0/R + volume phase ratio) of the partition between mobile and stationary phases, for several polar model compounds of pharmaceutical interest, were estimated in RP-LC for different flow-rates and using an octadecyl-silicagel stationary phase. The temperature range used to plot van't Hoff curves was 25–50°C, which is the usual range for separation in RP-LC. Below 20°C, van't Hoff plots become non-linear for all studied compounds, due to the changes of the balance between hydrophobic and solvophobic forces that influence the retention process. Other significant deviations were observed for one compound that is involved in inter-changeable tautomeric equilibria (as discussed for piroxicam). Regression parameters of the linear dependences obtained between retention (natural logarithm of retention factor, ln k') and reciprocal absolute temperature (1/T) together with the estimated phase ratio were used to calculate the ther...
Found
Nothing found, try to update filter.
Found
Nothing found, try to update filter.
Top-30
Journals
|
1
|
|
|
Chromatographia
1 publication, 33.33%
|
|
|
Mendeleev Communications
1 publication, 33.33%
|
|
|
1
|
Publishers
|
1
|
|
|
Springer Nature
1 publication, 33.33%
|
|
|
Elsevier
1 publication, 33.33%
|
|
|
1
|
- We do not take into account publications without a DOI.
- Statistics recalculated weekly.
Are you a researcher?
Create a profile to get free access to personal recommendations for colleagues and new articles.
Metrics
3
Total citations:
3
Citations from 2025:
0
Cite this
GOST |
RIS |
BibTex |
MLA
Cite this
GOST
Copy
Galaon T. et al. THE INFLUENCE OF MOBILE-PHASE FLOW-RATE IN RP-LC ON THERMODYNAMIC PARAMETERS STUDIED FOR POLAR COMPOUNDS // Journal of Liquid Chromatography and Related Technologies. 2011. Vol. 34. No. 7. pp. 521-536.
GOST all authors (up to 50)
Copy
Galaon T., Mihailciuc C., Medvedovici A., David V. THE INFLUENCE OF MOBILE-PHASE FLOW-RATE IN RP-LC ON THERMODYNAMIC PARAMETERS STUDIED FOR POLAR COMPOUNDS // Journal of Liquid Chromatography and Related Technologies. 2011. Vol. 34. No. 7. pp. 521-536.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1080/10826076.2011.556974
UR - https://doi.org/10.1080/10826076.2011.556974
TI - THE INFLUENCE OF MOBILE-PHASE FLOW-RATE IN RP-LC ON THERMODYNAMIC PARAMETERS STUDIED FOR POLAR COMPOUNDS
T2 - Journal of Liquid Chromatography and Related Technologies
AU - Galaon, T
AU - Mihailciuc, Constantin
AU - Medvedovici, Andrei
AU - David, Victor
PY - 2011
DA - 2011/03/26
PB - Taylor & Francis
SP - 521-536
IS - 7
VL - 34
SN - 1082-6076
SN - 1520-572X
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2011_Galaon,
author = {T Galaon and Constantin Mihailciuc and Andrei Medvedovici and Victor David},
title = {THE INFLUENCE OF MOBILE-PHASE FLOW-RATE IN RP-LC ON THERMODYNAMIC PARAMETERS STUDIED FOR POLAR COMPOUNDS},
journal = {Journal of Liquid Chromatography and Related Technologies},
year = {2011},
volume = {34},
publisher = {Taylor & Francis},
month = {mar},
url = {https://doi.org/10.1080/10826076.2011.556974},
number = {7},
pages = {521--536},
doi = {10.1080/10826076.2011.556974}
}
Cite this
MLA
Copy
Galaon, T., et al. “THE INFLUENCE OF MOBILE-PHASE FLOW-RATE IN RP-LC ON THERMODYNAMIC PARAMETERS STUDIED FOR POLAR COMPOUNDS.” Journal of Liquid Chromatography and Related Technologies, vol. 34, no. 7, Mar. 2011, pp. 521-536. https://doi.org/10.1080/10826076.2011.556974.