Open Access
Biological Evaluation of Several Coumarin Derivatives Designed as Possible Anti-inflammatory/Antioxidant Agents
Publication type: Journal Article
Publication date: 2003-01-01
scimago Q2
wos Q1
SJR: 0.857
CiteScore: 11.2
Impact factor: 5.4
ISSN: 14756366, 14756374
PubMed ID:
12751823
Drug Discovery
General Medicine
Pharmacology
Abstract
Several linear and angular coumarins designed and synthesised as possible anti-inflammatory and antioxidant agents were evaluated for their biological activities, using the carrageenin-induced rat paw oedema model. In general, the compounds were found to be potent anti-inflammatory agents. Compound (4) was found to possess protective properties in adjuvant-induced arthritis in rats. The compounds were found to interact with 1,1-diphenyl-2-picryl-hydrazyl stable free radical (DPPH) whereas most of them were essentially inactive in other tests. The anti-inflammatory activity seemed to be connected with their reducing activity. R(M) values were determined as an expression of their lipophilicity which was also calculated as clog P. Only a poor relationship existed between lipophilicity and anti-inflammatory activity.
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297
Total citations:
297
Citations from 2025:
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(5.39%)
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GOST
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Kontogiorgis C., Hadjipavlou-Litina D. Biological Evaluation of Several Coumarin Derivatives Designed as Possible Anti-inflammatory/Antioxidant Agents // Journal of Enzyme Inhibition and Medicinal Chemistry. 2003. Vol. 18. No. 1. pp. 63-69.
GOST all authors (up to 50)
Copy
Kontogiorgis C., Hadjipavlou-Litina D. Biological Evaluation of Several Coumarin Derivatives Designed as Possible Anti-inflammatory/Antioxidant Agents // Journal of Enzyme Inhibition and Medicinal Chemistry. 2003. Vol. 18. No. 1. pp. 63-69.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1080/1475636031000069291
UR - https://doi.org/10.1080/1475636031000069291
TI - Biological Evaluation of Several Coumarin Derivatives Designed as Possible Anti-inflammatory/Antioxidant Agents
T2 - Journal of Enzyme Inhibition and Medicinal Chemistry
AU - Kontogiorgis, Christos
AU - Hadjipavlou-Litina, Dimitra
PY - 2003
DA - 2003/01/01
PB - Taylor & Francis
SP - 63-69
IS - 1
VL - 18
PMID - 12751823
SN - 1475-6366
SN - 1475-6374
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2003_Kontogiorgis,
author = {Christos Kontogiorgis and Dimitra Hadjipavlou-Litina},
title = {Biological Evaluation of Several Coumarin Derivatives Designed as Possible Anti-inflammatory/Antioxidant Agents},
journal = {Journal of Enzyme Inhibition and Medicinal Chemistry},
year = {2003},
volume = {18},
publisher = {Taylor & Francis},
month = {jan},
url = {https://doi.org/10.1080/1475636031000069291},
number = {1},
pages = {63--69},
doi = {10.1080/1475636031000069291}
}
Cite this
MLA
Copy
Kontogiorgis, Christos, and Dimitra Hadjipavlou-Litina. “Biological Evaluation of Several Coumarin Derivatives Designed as Possible Anti-inflammatory/Antioxidant Agents.” Journal of Enzyme Inhibition and Medicinal Chemistry, vol. 18, no. 1, Jan. 2003, pp. 63-69. https://doi.org/10.1080/1475636031000069291.