Open Access
Research progress on the synthesis and pharmacology of 1,3,4-oxadiazole and 1,2,4-oxadiazole derivatives: a mini review
1
Institute of Pharmaceutical Chemistry and Pharmacology, Inner Mongolia Minzu University, Inner Mongolia Autonomous Region, Tongliao, PR China
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2
Inner Mongolia Key Laboratory of Mongolian Medicine Pharmacology for Cardio-Cerebral Vascular System, Inner Mongolia Autonomous Region, Tongliao, PR China
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Publication type: Journal Article
Publication date: 2022-08-23
scimago Q2
wos Q1
SJR: 0.857
CiteScore: 11.2
Impact factor: 5.4
ISSN: 14756366, 14756374
PubMed ID:
36000176
Drug Discovery
General Medicine
Pharmacology
Abstract
Oxadiazole is a five-membered heterocyclic compound containing two nitrogen atoms and one oxygen atom. The 1,3,4-oxadiazole and 1,2,4-oxadiazole have favourable physical, chemical, and pharmacokinetic properties, which significantly increase their pharmacological activity via hydrogen bond interactions with biomacromolecules. In recent years, oxadiazole has been demonstrated to be the biologically active unit in a number of compounds. Oxadiazole derivatives exhibit antibacterial, anti-inflammatory, anti-tuberculous, anti-fungal, anti-diabetic and anticancer activities. In this paper, we report a series of compounds containing oxadiazole rings that have been published in the last three years only (2020-2022) as there was no report or their activities described in any article in 2019, which will be useful to scientists in research fields of organic synthesis, medicinal chemistry, and pharmacology.
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Metrics
68
Total citations:
68
Citations from 2024:
53
(79.11%)
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GOST
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Wang J. J. et al. Research progress on the synthesis and pharmacology of 1,3,4-oxadiazole and 1,2,4-oxadiazole derivatives: a mini review // Journal of Enzyme Inhibition and Medicinal Chemistry. 2022. Vol. 37. No. 1. pp. 2304-2319.
GOST all authors (up to 50)
Copy
Wang J. J., Wen S., Jia W., Bian M., Yu L. Research progress on the synthesis and pharmacology of 1,3,4-oxadiazole and 1,2,4-oxadiazole derivatives: a mini review // Journal of Enzyme Inhibition and Medicinal Chemistry. 2022. Vol. 37. No. 1. pp. 2304-2319.
Cite this
RIS
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TY - JOUR
DO - 10.1080/14756366.2022.2115036
UR - https://doi.org/10.1080/14756366.2022.2115036
TI - Research progress on the synthesis and pharmacology of 1,3,4-oxadiazole and 1,2,4-oxadiazole derivatives: a mini review
T2 - Journal of Enzyme Inhibition and Medicinal Chemistry
AU - Wang, Jing Jing
AU - Wen, Sun
AU - Jia, Wei-Dong
AU - Bian, Ming
AU - Yu, Li-Jun
PY - 2022
DA - 2022/08/23
PB - Taylor & Francis
SP - 2304-2319
IS - 1
VL - 37
PMID - 36000176
SN - 1475-6366
SN - 1475-6374
ER -
Cite this
BibTex (up to 50 authors)
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@article{2022_Wang,
author = {Jing Jing Wang and Sun Wen and Wei-Dong Jia and Ming Bian and Li-Jun Yu},
title = {Research progress on the synthesis and pharmacology of 1,3,4-oxadiazole and 1,2,4-oxadiazole derivatives: a mini review},
journal = {Journal of Enzyme Inhibition and Medicinal Chemistry},
year = {2022},
volume = {37},
publisher = {Taylor & Francis},
month = {aug},
url = {https://doi.org/10.1080/14756366.2022.2115036},
number = {1},
pages = {2304--2319},
doi = {10.1080/14756366.2022.2115036}
}
Cite this
MLA
Copy
Wang, Jing Jing, et al. “Research progress on the synthesis and pharmacology of 1,3,4-oxadiazole and 1,2,4-oxadiazole derivatives: a mini review.” Journal of Enzyme Inhibition and Medicinal Chemistry, vol. 37, no. 1, Aug. 2022, pp. 2304-2319. https://doi.org/10.1080/14756366.2022.2115036.