Abietic, maleopimaric and quinopimaric dipeptide Ugi-4CR derivatives and their potency against influenza A and SARS-CoV-2
Elena Tretyakova
1
,
Xinyuan Ma
2, 3
,
Anna A. Shtro
4
,
Galina D Petukhova
4
,
Anna A. Smirnova
1
,
Huan Xu
2
,
Sulong Xiao
2
3
Institute of Chemical Biology, Shenzhen Bay Laboratory, Shenzhen, China
|
Publication type: Journal Article
Publication date: 2022-08-17
scimago Q2
wos Q3
SJR: 0.398
CiteScore: 5.2
Impact factor: 1.6
ISSN: 14786419, 14786427
PubMed ID:
35975755
Organic Chemistry
Biochemistry
Plant Science
Analytical Chemistry
Abstract
A set of 12 abietane diterpene derivatives have been synthesised by the Ugi-four component reaction (Ugi-4CR) and tested for cytotoxicity and activity against influenza virus A/Puerto Rico/8/34 (H1N1) and SARS-CoV-2 pseudovirus. Five dipeptide derivatives demonstrated a selectivity index (SI) higher than 10 and IC50 values from 2 to 32 μM against influenza virus. Compound 11 was found to be a lead with SI of 200, and time-of-addition experiments showed the viral entry into the cell and the binding of the virus to the receptor as a possible target. Compound 7 was the only one showed weak anti-SARS-CoV-2 activity with EC50 value of 80.96 µM. Taken together, our data suggest the potency of diterpene acids-Ugi products as new effective anti-influenza compounds.
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Total citations:
13
Citations from 2025:
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(15.38%)
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GOST
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Tretyakova E. et al. Abietic, maleopimaric and quinopimaric dipeptide Ugi-4CR derivatives and their potency against influenza A and SARS-CoV-2 // Natural Product Research. 2022. Vol. 37. No. 12. pp. 1954-1960.
GOST all authors (up to 50)
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Tretyakova E., Ma X., Kazakova O. B., Shtro A. A., Petukhova G. D., Smirnova A. A., Xu H., Xiao S. Abietic, maleopimaric and quinopimaric dipeptide Ugi-4CR derivatives and their potency against influenza A and SARS-CoV-2 // Natural Product Research. 2022. Vol. 37. No. 12. pp. 1954-1960.
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TY - JOUR
DO - 10.1080/14786419.2022.2112040
UR - https://www.tandfonline.com/doi/full/10.1080/14786419.2022.2112040
TI - Abietic, maleopimaric and quinopimaric dipeptide Ugi-4CR derivatives and their potency against influenza A and SARS-CoV-2
T2 - Natural Product Research
AU - Tretyakova, Elena
AU - Ma, Xinyuan
AU - Kazakova, Oxana B.
AU - Shtro, Anna A.
AU - Petukhova, Galina D
AU - Smirnova, Anna A.
AU - Xu, Huan
AU - Xiao, Sulong
PY - 2022
DA - 2022/08/17
PB - Taylor & Francis
SP - 1954-1960
IS - 12
VL - 37
PMID - 35975755
SN - 1478-6419
SN - 1478-6427
ER -
Cite this
BibTex (up to 50 authors)
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@article{2022_Tretyakova,
author = {Elena Tretyakova and Xinyuan Ma and Oxana B. Kazakova and Anna A. Shtro and Galina D Petukhova and Anna A. Smirnova and Huan Xu and Sulong Xiao},
title = {Abietic, maleopimaric and quinopimaric dipeptide Ugi-4CR derivatives and their potency against influenza A and SARS-CoV-2},
journal = {Natural Product Research},
year = {2022},
volume = {37},
publisher = {Taylor & Francis},
month = {aug},
url = {https://www.tandfonline.com/doi/full/10.1080/14786419.2022.2112040},
number = {12},
pages = {1954--1960},
doi = {10.1080/14786419.2022.2112040}
}
Cite this
MLA
Copy
Tretyakova, Elena, et al. “Abietic, maleopimaric and quinopimaric dipeptide Ugi-4CR derivatives and their potency against influenza A and SARS-CoV-2.” Natural Product Research, vol. 37, no. 12, Aug. 2022, pp. 1954-1960. https://www.tandfonline.com/doi/full/10.1080/14786419.2022.2112040.