Open Access

mAbs, volume 12, issue 1

Potent neutralization of SARS-CoV-2 by human antibody heavy-chain variable domains isolated from a large library with a new stable scaffold

Zehua Sun ¹

Chuan Chen ¹

Wei Li ¹

David G. Martinez ²

David R. Martinez ²

Aleksandra Drelich ³

Aleksandra K Drelich ³

Du-San Baek ¹

Xianglei Liu ¹

John W. Mellors ^{1, 4}

Chien-Te Tseng ³

Chien-Hao Tseng ³

Ralph Baric ²

Ralph S Baric ²

Dimiter S. Dimitrov ^{1, 4}

Hide authors affiliations Show authors affiliations: 4 affiliations

Center for Antibody Therapeutics, Division of Infectious Diseases, Department of Medicine, University of Pittsburgh Medical School, Pittsburgh, PA, USA |

Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA |

Department of Microbiology & Immunology, Centers for Biodefense and Emerging Diseases, Galveston National Laboratory, Galveston, TX, USA |

⁴

Abound Bio, Pittsburgh, PA, USA |

Publication type: Journal Article

Publication date: 2020-01-01

Taylor & Francis

Journal: mAbs

Quartile SCImago

Quartile WOS

Impact factor: 5.3

ISSN: 19420862, 19420870

DOI: 10.1080/19420862.2020.1778435

Copy DOI

Immunology

Immunology and Allergy

Abstract

Effective therapies are urgently needed for COVID-19. Here we describe the identification of a new stable human immunoglobulin G1 heavy-chain variable (VH) domain scaffold that was used for the construction of a large library, lCAT6, of engineered human VHs. This library was panned against the receptor-binding domain (RBD) of the SARS-CoV-2 spike (S) glycoprotein. Two VH domains (VH ab6 and VH m397) were selected and fused to Fc for increased half-life in circulation. The VH-Fc ab6 and m397 specifically neutralized SARS-CoV-2 with high potencies (50% neutralization at 0.35 µg/ml and 1.5 µg/ml, respectively) as measured by two independent replication-competent virus neutralization assays. Ab6 and m397 competed with ACE2 for binding to RBD, suggesting a competitive mechanism of virus neutralization. These VH domains may have potential applications for prophylaxis and therapy of COVID-19 alone or in combination, as well as for diagnosis and as tools for research.

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Citations by journals

	1 2 3
Frontiers in Immunology	Frontiers in Immunology, 3, 5.17% Frontiers in Immunology 3 publications, 5.17%
International Journal of Molecular Sciences	International Journal of Molecular Sciences, 2, 3.45% International Journal of Molecular Sciences 2 publications, 3.45%
OMICS A Journal of Integrative Biology	OMICS A Journal of Integrative Biology, 1, 1.72% OMICS A Journal of Integrative Biology 1 publication, 1.72%
Cell Biochemistry and Function	Cell Biochemistry and Function, 1, 1.72% Cell Biochemistry and Function 1 publication, 1.72%
Frontiers in Molecular Biosciences	Frontiers in Molecular Biosciences, 1, 1.72% Frontiers in Molecular Biosciences 1 publication, 1.72%
Frontiers in Cellular and Infection Microbiology	Frontiers in Cellular and Infection Microbiology, 1, 1.72% Frontiers in Cellular and Infection Microbiology 1 publication, 1.72%
Journal of Nanobiotechnology	Journal of Nanobiotechnology, 1, 1.72% Journal of Nanobiotechnology 1 publication, 1.72%
Scientific Reports	Scientific Reports, 1, 1.72% Scientific Reports 1 publication, 1.72%
Microbial Cell Factories	Microbial Cell Factories, 1, 1.72% Microbial Cell Factories 1 publication, 1.72%
Cellular and Molecular Immunology	Cellular and Molecular Immunology, 1, 1.72% Cellular and Molecular Immunology 1 publication, 1.72%
Clinical Reviews in Allergy and Immunology	Clinical Reviews in Allergy and Immunology, 1, 1.72% Clinical Reviews in Allergy and Immunology 1 publication, 1.72%
Signal Transduction and Targeted Therapy	Signal Transduction and Targeted Therapy, 1, 1.72% Signal Transduction and Targeted Therapy 1 publication, 1.72%
Nature Communications	Nature Communications, 1, 1.72% Nature Communications 1 publication, 1.72%
Nature Chemical Biology	Nature Chemical Biology, 1, 1.72% Nature Chemical Biology 1 publication, 1.72%
npj Regenerative Medicine	npj Regenerative Medicine, 1, 1.72% npj Regenerative Medicine 1 publication, 1.72%
Science China Life Sciences	Science China Life Sciences, 1, 1.72% Science China Life Sciences 1 publication, 1.72%
Molecular Immunology	Molecular Immunology, 1, 1.72% Molecular Immunology 1 publication, 1.72%
Research in Veterinary Science	Research in Veterinary Science, 1, 1.72% Research in Veterinary Science 1 publication, 1.72%
iScience	iScience, 1, 1.72% iScience 1 publication, 1.72%
PLoS ONE	PLoS ONE, 1, 1.72% PLoS ONE 1 publication, 1.72%
Cell	Cell, 1, 1.72% Cell 1 publication, 1.72%
Vaccine	Vaccine, 1, 1.72% Vaccine 1 publication, 1.72%
Cellular Immunology	Cellular Immunology, 1, 1.72% Cellular Immunology 1 publication, 1.72%
Cell Reports	Cell Reports, 1, 1.72% Cell Reports 1 publication, 1.72%
Advanced Drug Delivery Reviews	Advanced Drug Delivery Reviews, 1, 1.72% Advanced Drug Delivery Reviews 1 publication, 1.72%
Cell Host and Microbe	Cell Host and Microbe, 1, 1.72% Cell Host and Microbe 1 publication, 1.72%
STAR Protocols	STAR Protocols, 1, 1.72% STAR Protocols 1 publication, 1.72%
FASEB Journal	FASEB Journal, 1, 1.72% FASEB Journal 1 publication, 1.72%
Advanced Therapeutics	Advanced Therapeutics, 1, 1.72% Advanced Therapeutics 1 publication, 1.72%
	1 2 3

Citations by publishers

	2 4 6 8 10 12
Elsevier	Elsevier, 11, 18.97% Elsevier 11 publications, 18.97%
Cold Spring Harbor Laboratory	Cold Spring Harbor Laboratory, 11, 18.97% Cold Spring Harbor Laboratory 11 publications, 18.97%
Springer Nature	Springer Nature, 10, 17.24% Springer Nature 10 publications, 17.24%
Frontiers Media S.A.	Frontiers Media S.A., 6, 10.34% Frontiers Media S.A. 6 publications, 10.34%
Wiley	Wiley, 5, 8.62% Wiley 5 publications, 8.62%
Multidisciplinary Digital Publishing Institute (MDPI)	Multidisciplinary Digital Publishing Institute (MDPI), 4, 6.9% Multidisciplinary Digital Publishing Institute (MDPI) 4 publications, 6.9%
Oxford University Press	Oxford University Press, 2, 3.45% Oxford University Press 2 publications, 3.45%
Mary Ann Liebert	Mary Ann Liebert, 1, 1.72% Mary Ann Liebert 1 publication, 1.72%
Public Library of Science (PLoS)	Public Library of Science (PLoS), 1, 1.72% Public Library of Science (PLoS) 1 publication, 1.72%
Federation of American Societies for Experimental Biology (FASEB)	Federation of American Societies for Experimental Biology (FASEB), 1, 1.72% Federation of American Societies for Experimental Biology (FASEB) 1 publication, 1.72%
Taylor & Francis	Taylor & Francis, 1, 1.72% Taylor & Francis 1 publication, 1.72%
American Society for Microbiology	American Society for Microbiology, 1, 1.72% American Society for Microbiology 1 publication, 1.72%
Proceedings of the National Academy of Sciences (PNAS)	Proceedings of the National Academy of Sciences (PNAS), 1, 1.72% Proceedings of the National Academy of Sciences (PNAS) 1 publication, 1.72%
Wolters Kluwer Health	Wolters Kluwer Health, 1, 1.72% Wolters Kluwer Health 1 publication, 1.72%
American Chemical Society (ACS)	American Chemical Society (ACS), 1, 1.72% American Chemical Society (ACS) 1 publication, 1.72%
Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii	Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii, 1, 1.72% Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii 1 publication, 1.72%
	2 4 6 8 10 12

We do not take into account publications without a DOI.
Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
Statistics recalculated weekly.

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GOST Copy

Sun Z. et al. Potent neutralization of SARS-CoV-2 by human antibody heavy-chain variable domains isolated from a large library with a new stable scaffold // mAbs. 2020. Vol. 12. No. 1.

GOST all authors (up to 50) Copy

Sun Z., Chen C., Li W., Li W., Martinez D. R., Martinez D. G., Drelich A., Drelich A. K., Baek D., Liu X., Mellors J. W., Tseng C., Tseng C., Baric R. S., Baric R., Dimitrov D. S. Potent neutralization of SARS-CoV-2 by human antibody heavy-chain variable domains isolated from a large library with a new stable scaffold // mAbs. 2020. Vol. 12. No. 1.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1080/19420862.2020.1778435

UR - https://doi.org/10.1080/19420862.2020.1778435

TI - Potent neutralization of SARS-CoV-2 by human antibody heavy-chain variable domains isolated from a large library with a new stable scaffold

T2 - mAbs

AU - Sun, Zehua

AU - Li, Wei

AU - Martinez, David R.

AU - Drelich, Aleksandra

AU - Baek, Du-San

AU - Liu, Xianglei

AU - Mellors, John W.

AU - Tseng, Chien-Te

AU - Baric, Ralph S

AU - Dimitrov, Dimiter S.

AU - Chen, Chuan

AU - Li, Wei

AU - Martinez, David G.

AU - Drelich, Aleksandra K

AU - Tseng, Chien-Hao

AU - Baric, Ralph

PY - 2020

DA - 2020/01/01 00:00:00

PB - Taylor & Francis

IS - 1

VL - 12

SN - 1942-0862

SN - 1942-0870

ER -

BibTex

Cite this

BibTex Copy

@article{2020_Sun,

author = {Zehua Sun and Wei Li and David R. Martinez and Aleksandra Drelich and Du-San Baek and Xianglei Liu and John W. Mellors and Chien-Te Tseng and Ralph S Baric and Dimiter S. Dimitrov and Chuan Chen and Wei Li and David G. Martinez and Aleksandra K Drelich and Chien-Hao Tseng and Ralph Baric},

title = {Potent neutralization of SARS-CoV-2 by human antibody heavy-chain variable domains isolated from a large library with a new stable scaffold},

journal = {mAbs},

year = {2020},

volume = {12},

publisher = {Taylor & Francis},

month = {jan},

url = {https://doi.org/10.1080/19420862.2020.1778435},

number = {1},

doi = {10.1080/19420862.2020.1778435}

}

Found error?

Publisher

Taylor & Francis

Journal

mAbs

Quartile SCImago

Quartile WOS

Impact factor

5.3

ISSN

19420862 (Print)
19420870 (Electronic)